Tropomyosin receptor kinase B (TrkB), [5] [6] [7] also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. [8] TrkB is a receptor for brain-derived neurotrophic factor (BDNF). [9] [10] The standard pronunciation for this protein is "track bee".

(A) Schematic representation of the genomic structure of the murine TrkB gene. Exons are shown as boxes and introns are shown as lines. White and black stars indicate the start and stop condons, respectively. Color of exons indicate the domains of the TrkB protein isoforms shown in panel (B).Gray boxes indicate the 3′ untranslated region (UTR) of the TrkB transcripts.

Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase receptor type B (TrkB) are widely distributed in multiple regions of the human brain. Specifically, BDNF/TrkB is highly expressed and activated in the dopaminergic ...

While mature BDNF can be secreted constitutively, it is preferentially released via a tightly controlled regulated pathway driven by activity-dependent depolarisation and Ca 2+ entry 12.We first tested whether the E183K BDNF variant had any functional impact on BDNF globally, by transfecting wild-type (WT) and mutant BDNF into PC12 cells, which stably express human …

2020年6月3日 · Brain-derived neurotrophic factor (BDNF) signals through its high affinity receptor Tropomyosin receptor kinase-B (TrkB) to regulate neuronal development, synapse formation and plasticity. In rodents, genetic disruption of Bdnf and TrkB leads to weight gain and a spectrum of neurobehavioural phenoty …

2024年3月2日 · TrkB (neuronal receptor tyrosine kinase-2, NTRK2) is the receptor for brain-derived neurotrophic factor (BDNF) and is a critical regulator of activity-dependent neuronal plasticity. The past few years have witnessed an increasing understanding of the structure and function of TrkB, including its transmembrane domain (TMD). TrkB interacts with membrane …

2024年1月1日 · As one of the most prevalent neurotrophic factors in the central nervous system (CNS), brain-derived neurotrophic factor (BDNF) plays a significant role in CNS injury by binding to its specific receptor Tropomyosin-related kinase receptor B (TrkB). The BDNF/TrkB signaling pathway is crucial for neur …

2024年1月1日 · Mature neurotrophic factors primarily function as non-covalently linked homodimers, such as NT-3/NT-3. However, some neurotrophic factors can also form heterodimers with other neurotrophic factors, for instance, known heterodimers like NT-3/BDNF and NT-4/BDNF, which play a role in neuronal protection [8].Neurotrophic factors exert …

2020年6月3日 · The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) is widely expressed in the mammalian brain and signals via the Tropomyosin receptor kinase B (TrkB) to regulate neuronal differentiation ...

Summary. trkB is a tyrosine protein kinase gene highly related to trk, a proto-oncogene that encodes a receptor for nerve growth factor (NGF) and neurotrophin-3 (NT-3).trkB expression is confined to structures of the central and peripheral nervous systems, suggesting it also encodes a receptor for neurotrophic factors.Here we show that brain-derived neurotrophic factor (BDNF) …