2019年1月1日 · The tumor necrosis factor (TNF) and TNF receptor (TNFR) superfamilies (TNFSF/TNFRSF) include 19 ligands and 29 receptors that play important roles in the modulation of cellular functions. The communication pathways mediated by TNFSF/TNFRSF are essential for numerous developmental, homeostatic, and s …

Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent therapeutic targets for cancer and autoimmunity. We review the latest literature on TNF receptor superfamily signaling with a focus on structure-function.

Receptors in the TNFSF family activate diverse cellular functions, from production of type 1 interferons to the modulation of survival of antigen-activated T cells. Here, we focus attention on the subset of TNF superfamily receptors encoded on the immune response locus at Chr 1p36.

Tumor necrosis factor (TNF) superfamily pathways regulate cell proliferation, cell death, and morphogenesis. TNF superfamily receptors mediate various cancers and immune-mediated diseases.

2024年10月24日 · Here, we provide an overview of the past and current clinical trials targeting individual TNFSF or TNFRSF members in autoimmune and inflammatory disease and cancer. We describe the range of...

2013年1月21日 · TNF receptor superfamily (TNFRSF) molecules contain variable numbers of cysteine-rich domains in their ligand-binding extracellular regions (ectodomains).

Historically, tumor necrosis factor superfamily (TNFSF) ligands have been identified as proinflammatory mediators; however, our group has pioneered work implicating the TNF superfamily members in fibrosis (2 – 5). Currently, the TNF superfamily is known to consist of 19 ligands and 29 receptors.

2022年7月5日 · Tumor necrosis factor receptor superfamily (TNFRSF) members such as CD40, OX40 and CD137/4-1BB are expressed on myeloid cells and/or lymphocytes, and they regulate antigen presentation and adaptive immune activities.

2020年3月20日 · Tumor necrosis factor (TNF) superfamily ligands show diverse biological functions, such as the induction of apoptotic cell death or cell survival and proliferation, making them excellent therapeutic targets for cancer and autoimmunity. We review the latest literature on TNF receptor superfamily signaling with a focus on structure-function.

2019年3月4日 · Antibodies specific for TNFRSF receptors that bind soluble ligands without getting properly activated generally act as strong agonists upon FcγR binding. Systematic analyses revealed that the FcγR dependency of such antibodies to act as potent agonists is largely independent from isotype, FcγR type, and of the epitope recognized.