2020年12月23日 · Thioacetal/thioketal moieties have been identified as responsive to reactive oxygen species (ROS). Despite its utility in a broad range of applications, the mechanism that underlies the ROS-induced cleavage of these moieties is not well understood.

2024年9月19日 · This study designed a novel reactive oxygen species-responsive thioketal cyclodextrin metal-organic framework (TCOF) and dexamethasone-loaded TCOF nanoparticles (TCD) are employed for inflammation-ta...

2020年10月1日 · With the utilization of high concentration reactive oxygen species (ROS) in tumor microenvironment, PEG-doxorubicin (PEG-DOX) prodrug was synthesized via a thioketal moiety as the linker, which was ROS cleavable to trigger DOX release from the …

2019年4月12日 · For the polyprodrug design in this work, CPT was covalently tethered by a thioketal linker in the side chain of polyprodrug amphiphiles, exhibiting potential ROS-responsive drug release.

2022年10月4日 · We prepared degradable thermoset materials using thioketal (TK) cross-linkers, which underwent main-chain or side change degradation in the presence of hydrogen peroxide in water.

A new heterobifunctional reactive oxygen species (ROS) responsive thioketal linker and its synthesis are described. This linker allows for developing new ROS-responsive agents with two distinct functionalities using universal bioconjugation methods. ...

2022年2月11日 · Of particular interest, the thioketal (TK) moiety is being increasingly cited in the literature for new and innovative applications, especially in cancer and inflammatory diseases.

Of particular interest, the thioketal (TK) moiety is being increasingly cited in the literature for new and innovative applications, especially in cancer and inflammatory diseases.

2022年2月28日 · A thioketal is the sulfur analog of a ketal. eg. 1: eg. 2: eg. 3: see also cyclic thioketal

2019年8月1日 · In this study, we synthesized a novel ROS-responsive poly (β-amino ester) (PBAEROS) through introduction of thioketal groups in its monomer structure and use.