tert-Butyldimethylsilyl chloride is an organosilicon compound with the formula (Me 3 C)Me 2 SiCl (Me = CH 3). It is commonly abbreviated as TBSCl or TBDMSCl. It is a chlorosilane containing two methyl groups and a tert -butyl group. As such it is more bulky that trimethylsilyl chloride.

A sequential one-pot synthesis for the oxidation of primary and secondary tert-butyldimethylsilyl (TBDMS) ethers, using the presence of PhIO or PhI(OAc) 2 and catalytic amounts of metal triflates and TEMPO in THF or acetonitrile tolerates acid-sensitive protecting groups and leaves tert-butyldiphenylsilyl ethers and phenolic TBDMS groups untouched.

What is the TBS Protecting Group? TBS or TBDMS is short for tert – b utyl d i m ethyl s ilyl, a protecting group for alcohols. TBS was introduced by the legendary E. J. Corey in 1972 [1] as an evolution to simpler silyl ethers which had already been known.

Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.

tert -Butyldimethylsilyl chloride (TBDMSCl) is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids. [1] [2] It is also used in the preparation of isoxazoline N -oxides from α-bromonitroalkanes and olefins. [3] .

As an alternative, 6- O - tert -butyldimethylsilyl-2,3-di- O-methyl)-β-cyclodextrin (β-TBDM) has been used in several works. Probably the most pronounced differences in the quality are available ranging from very pure CSP to something classified as randomly siliylated.

Visit Product Comparison Guide. This reagent was used to introduce a bulky tert -butyl dimethylsilyl group onto a cis -bis (alkenyl)oxirane facilitating a room temperature Cope rearrangement to a 2-CF 3 -4,5-dihydrooxepin. [1] Together with a thiolane promotes a rapid and efficient chalcogenide-Morita-Baylis-Hillman reaction. [2]

tert-Butyldiphenylsilyl, also known as TBDPS, is a protecting group for alcohols. Its formula is C 16 H 19 Si-. [1] The tert -butyldiphenylsilyl group was first suggested as a protecting group by Hanessian and Lavallée in 1975. It was designed to supersede the use of Corey's tert -butyldimethylsilyl as a protecting group for alcohols:

tert-Butyldimethylsilyl chloride (TBDMSCL) is often used as a protect agent in organic synthesis. The hydroxyl functionality has been found to be effectively protected by transformation to the silyl ether by reaction with tert-Butyldimethylsilyl chloride. In the synthesis of organic compounds, protection groups are used extensively.

tert-Butyldimethylsilyl chloride (TBDMS-Cl) is a silylating agent used to protect hydroxyl (OH) groups in organic synthesis. It is a key reagent in the protection of alcohols, a common step in the synthesis of complex organic molecules.