
TRPC6 - Wikipedia
TRPC6 channels are extensively present throughout the kidney, both in the tubular segments and the glomeruli.Within the glomeruli, expression of TRPC6 is primarily concentrated in …
Structure of the receptor-activated human TRPC6 and TRPC3 …
2018年4月26日 · Discovery of a high-affinity inhibitor for hTRPC6. Gain-of-function mutations in human TRPC6 can lead to excessive calcium influx in kidney podocytes and familial FSGS. 20 …
瞬时受体电位阳离子通道亚家族 C 成员 6(TRPC6)基因 | MCE
瞬时受体电位阳离子通道亚家族 C 成员 6: 由该基因编码的蛋白质在细胞膜中形成受体激活的钙通道。该通道由甘油二酯激活,并被认为受磷脂酰肌醇第二信使系统的控制。该通道的激活独立 …
TRPC6 Gene - GeneCards | TRPC6 Protein | TRPC6 Antibody
2024年12月25日 · TRPC6 (Transient Receptor Potential Cation Channel Subfamily C Member 6) is a Protein Coding gene. Diseases associated with TRPC6 include Focal Segmental …
TRPC6: physiological function and pathophysiological relevance
TRPC6 is a non-selective cation channel 6 times more permeable to Ca(2+) than to Na(+). Channel homotetramers heterologously expressed have a characteristic doubly rectifying …
Transient Receptor Potential Canonical (TRPC) Channels: Then …
TRPC6-dependent constitutive activation of calcineurin-NFAT pathway was reported to contribute to the progression of FSGS . TRPC6 activity was found to regulate actin stress fiber formation …
瞬时受体电位阳离子通道蛋白6在缺血-再灌注损伤中的作用研究进展
瞬时受体电位阳离子通道蛋白6(trpc6)是ca 2+ 通道家族中的一员,在多种细胞中高表达,可通过调节细胞内ca 2+ 浓度参与多项生理功能的调控,已成为研发治疗多种疾病药物的重要靶点 …
TRPC6 transient receptor potential cation channel subfamily C …
TRPC6-protein expression in the elderly and in liver disease. Mechanosensitive cation currents through TRPC6 and Piezo1 channels in human pulmonary arterial endothelial cells. TRPC6 …
肾小管生理学和病理生理学中的TRPC通道:我们知道什么?|肾细 …
2023年3月1日 · trpc6-nfatc1通路的抑制显着降低了ccrcc细胞的存活和增殖。这些结果等支持wnk1驱动的trpc6-nfatc1通路是ccrcc细胞增殖和迁移的关键组成部分[93]。相比之下,对人转 …
学术讲座|王以政院士 TRPC6与阿尔茨海默病判断 - 新闻中心 - 昌 …
2025年3月21日 · trpc6通过介导脑源性神经营养因子(bdnf)诱导的神经元生存机制,促进神经结构和功能可塑性。研究发现,trpc6的减少与ad或认知障碍的发生密切相关。在ad小鼠模型 …
- 某些结果已被删除