TNF receptor-associated factor (TRAF3) is a protein that in humans is encoded by the TRAF3 gene. [5][6][7] The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily.

2024年12月25日 · TRAF3 (TNF Receptor Associated Factor 3) is a Protein Coding gene. Diseases associated with TRAF3 include Encephalopathy, Acute, Infection-Induced 5 and Candidiasis, Familial, 6. Among its related pathways are Toll Like Receptor 7/8 (TLR7/8) Cascade and TNFR1 Pathway.

2013年6月13日 · TRAF3 regulates NLRP12-mediated suppression of TLR-driven NF-κB activation, as NLRP12 interacts with both NIK and TRAF3 . TRAF6 interacts with NLRX1, which negatively regulates NF-κB activation induced by RIG-I or TLR4 [ 118 , 119 ].

2018年6月19日 · Our study offers insights into mechanisms of TRAF3 modulation and provides potential therapeutic targets against infections by intracellular bacteria and inflammatory diseases.

2023年1月26日 · In a recent proteomic study, we identified the key mitochondrial fission factor, MFF, as a new interacting protein of TRAF3, a known tumor suppressor of multiple myeloma and other B cell malignancies.

2024年11月23日 · TRAF3, a versatile adaptor protein within the TRAF family, participates in various signaling pathways involving the tumor necrosis factor receptor, toll-like receptor, and retinoic acid-inducible gene I-like receptor families.

2025年2月14日 · TRAF3 coordinates the IL-6R/IL-2R–BCL6 signaling nexus during systemic infection to promote epigenetic and transcriptomic pro-grams that are essential for initial T FH cell specification, commit-ment, and function. The identification of TRAF3 as a critical regulator of T FH differentiation may lead to strategies to either enhance or re-strain T

2018年1月1日 · TRAF3 is an important adaptor protein regulating intracellular signaling through cell surface receptors.

2024年4月23日 · Knockout of TRAF3, DYRK1A, or RAD54L2 reduces the mRNA levels of ACE2 and inhibits the cellular entry of SARS-CoV-2. On the other hand, SARS-CoV-2 continuously evolves by genetic mutations for the adaption to the host.

2024年12月25日 · TRAF3IP3 (TRAF3 Interacting Protein 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is SLMAP. Adapter protein that plays essential roles in both innate and adaptive immunity.