2024年12月25日 · TGFBR1 (Transforming Growth Factor Beta Receptor 1) is a Protein Coding gene. Diseases associated with TGFBR1 include Multiple Self-Healing Squamous Epithelioma and Loeys-Dietz Syndrome 1. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and TGFBR2 Kinase Domain Mutants in Cancer.

Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound TGF beta receptor protein of the TGF-beta receptor family for the TGF beta superfamily of signaling ligands. TGFBR1 is its human gene.

The TGFBR1 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 1. This receptor transmits signals from the cell surface into the cell through a process called signal transduction.

Gene ID: 7046, updated on 8-Feb-2025. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein …

Focusing on the receptors in events in and beyond TGF-β signaling, we review the membrane trafficking of TGFBRs, the kinase activity of TGFBR1 and 2, the direct interactions between TGFBR2 and other receptors, and the novel roles of TGFBR3.

The TGFBR1 gene encodes a serine/threonine kinase receptor for transforming growth factor-beta (TGFB1; 190180). Most growth factor receptors are transmembrane tyrosine kinases or are associated with cytoplasmic tyrosine kinases.

6 天之前 · TGFBR1 and TGFBR2 share a conserved serine/threonine kinase domain essential for phosphorylation-based signal transduction, while TGFBR3 lacks kinase activity but has extracellular domains crucial for ligand presentation. TGFBR1 consists of an extracellular ligand-binding domain, a transmembrane segment, and a cytoplasmic kinase domain.

2025年2月20日 · Title: TGFβR1 inhibition drives hepatocellular carcinoma proliferation through induction of toll-like-receptor signalling. Exosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-betaR1/Smad axis.

2025年1月4日 · Go to complete Gene record for TGFBR1; Go to Variation Viewer for TGFBR1 variants; Summary. The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase.

TGFBR1 *6A (*6A) is a common hypomorphic variant of the type I TGF-β receptor gene (TGFBR1) that has been associated with risk for several forms of cancer, in particular breast cancer. Several epidemiological studies have suggested that patients who carry the *6A allele have an increased risk of breast cancer.