Transcription factor E3 is a protein that in humans is encoded by the TFE3 gene. [5][6][7] TFE3, a member of the helix-loop-helix family of transcription factors, binds to the mu-E3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types (Henthorn et al., 1991). [supplied by OMIM] [7]

2022年5月23日 · TFE3 fusions are most closely associated with Xp11 translocation renal cell carcinoma, alveolar soft part sarcoma, melanotic Xp11 renal cell carcinoma, some PEComas and others. Although increased TFE3 expression is seen in some solid pseudopapillary pancreatic neoplasms, these have been negative for the gene fusion.

2024年12月25日 · TFE3 (Transcription Factor Binding To IGHM Enhancer 3) is a Protein Coding gene. Diseases associated with TFE3 include Intellectual Developmental Disorder, X-Linked, Syndromic, With Pigmentary Mosaicism And Coarse Facies and …

2023年3月11日 · TFE3 participates in the metabolism of energy in the body by regulating pathways such as glucose and lipid metabolism, mitochondrial metabolism, and autophagy. This review summarizes and...

In this work, we gather the available data regarding the key clinical and pathological features of these TFE3-rearranged renal epithelial and mesenchymal neoplasms. We seek to propose a comprehensive solution regarding their pathogenesis and sort out their classification conundrum.

Transcription factor binding to IGHM enhancer 3 (TFE3) is a gene that encodes a protein that promotes the expression of genes downstream of transforming growth factor beta signaling.

The TFE3 gene is encoded by 14,749 base pairs (bp) on chromosome Xp11.22 and produces a 3,431-bp mRNA transcript consisting of a 238-bp 5′ untranslated region (UTR) followed by ten coding exons and a 1,427-bp 3′ UTR (NM_006521.4). The coding region includes a start codon in exon 1 and stop codon in exon 10.

2021年9月6日 · TFE3 -translocation renal cell carcinoma (TFE3 -tRCC) is a rare and heterogeneous subtype of kidney cancer with no standard treatment for advanced disease. We describe comprehensive...

The TFE3 gene encodes a transcription factor involved in the regulation of many proteins implicated in carcinogenesis, including TGF, Met, Rb, Folliculin, Ets, and E-cadherin. It is believed that the fusion promotes tumorigenesis by causing dysregulated transcriptional TFE3 activity.

1 天前 · TFE3 and TFEB are members of the microphthalmia-associated transcription (MiT) family that regulate lysosomal function, nutrient/stress response and drug resistance (Raben and Puertollano, 2016).Translocation renal cell carcinomas (tRCC) are characterized by genetic translocation events involving one member of the (MiT) family, most frequently TFE3 (90% of …