Metalloreductase STEAP1 is an enzyme that in humans is encoded by the STEAP1 gene. [5] This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines.

2012年5月1日 · STEAP1 actively increases intra- and intercellular communication through the modulation of Na +, Ca 2+, and K + concentration, as well as the concentration of small molecules. It stimulates cancer cell proliferation and tumor invasiveness.

2023年10月16日 · STEAP1 is now drawing attention as a promising therapeutic target because of its tumor specificity and membrane-bound localization. The clinical efficacy of an antibody-drug conjugate targeting STEAP1 in metastatic, castration-resistant, prostate cancer was demonstrated in a phase 1 trial.

• STEAP1 is a membrane protein that is overexpressed in > 80% of prostate cancers, representing an attractive target for treating mCRPC 11-13 • Several modalities are being investigated to target STEAP1 11,17

2024年12月25日 · STEAP1 (STEAP Family Member 1) is a Protein Coding gene. Diseases associated with STEAP1 include Menkes Disease and Ewing Sarcoma . Among its related pathways are Copper homeostasis and Glucose / Energy Metabolism .

2024年1月12日 · Xaluritamig (AMG 509) is a six-transmembrane epithelial antigen of the prostate 1 (STEAP1)–targeted T-cell engager designed to facilitate lysis of STEAP1-expressing cancer cells, such as those in advanced prostate cancer.

2024年7月3日 · AMG 509 is a humanized T-cell engager (TCE) molecule targeting STEAP1, which has shown promising results in phase I trials for metastatic castration-resistant prostate cancer (mCRPC), with a monotherapy PSA50 of 49% and …

2025年1月6日 · ADRX-0405 is a next-generation antibody-drug conjugate (ADC) composed of a humanized IgG1 antibody targeting six-transmembrane epithelial antigen of the prostate 1 (STEAP1), a cell surface protein that is upregulated in prostate cancer and certain other cancers, yet has limited expression in normal healthy tissue.

STEAP1 is an antigen that promotes cancer growth and spread and is found to be broadly expressed in mCRPC tissues. STEAP1 CART is composed of CAR T cells that have been engineered with a STEAP1 antigen to better target prostate tumor cells.

3 天之前 · STEAP1-targeted therapy includes an antibody–drug conjugate (ADC), chimeric antigen receptor T cell (CAR-T), T-cell engager (TCE), and vaccines, which demonstrate valuable therapeutic prospects. This review presents the structure and pathophysiological function of STEAP1, synthesizes cutting-edge advances in STEAP1-targeted molecular imaging ...