2024年12月25日 · SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2) is a Protein Coding gene. Diseases associated with SREBF2 include Hypercholesterolemia, Familial, 1 and Bardet-Biedl Syndrome 18. Among its related pathways are Transcriptional regulation of white adipocyte differentiation and Metabolism of steroids.

Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 (SREBF2) is a protein that in humans is encoded by the SREBF2 gene. [5]

Vergnes et al. reveal how loss of Srebp2 (Srebf2) in the mouse greatly compromises expression of both Srebp1a and Srebp1c in the liver (asterisk), which are cotranscribed from the same locus (Srebf1) and differ in their 5′ exons, causing defects in both hepatic cholesterol and fatty acid synthesis. Vergnes et al. also describe how defects in ...

2023年11月29日 · Cholesterol homeostasis is under tight regulation at the transcriptional and post-transcriptional level. Sterol regulatory element-binding protein 2 (SREBP2, encoded by the SREBF2 gene)...

The lipogenesis regulator SREBF2 directly induces transcription of the iron carrier Transferrin (TF), reducing intracellular iron pools, reactive oxygen species (ROS) and lipid peroxidation, thereby conferring resistance to inducers of ferroptosis.

2025年3月4日 · Title: Dominant missense variants in SREBF2 are associated with complex dermatological, neurological, and skeletal abnormalities. Hyperactivation of SREBP induces pannexin-1-dependent lytic cell death.

2022年9月12日 · Chromatin immunoprecipitation sequencing (ChIP-seq) analyses reveals that sterol regulatory element-binding proteins (SREBPs), the master regulatory TFs of lipid metabolism, are preferentially...

2011年3月2日 · The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus ...

2025年1月5日 · SREBF2 triggers endoplasmic reticulum stress and Bax dysregulation to promote lipopolysaccharide-induced endothelial cell injury. Association of SREBF-2 gene polymorphisms with the risk of developing type 2 diabetes mellitus.

2023年5月18日 · Here, we identify SREBP2 as a novel substrate for USP28, a deubiquitinating enzyme that is frequently upregulated in squamous cancers. Our results show that silencing of USP28 reduces expression...