Sphingosine kinase 1 - Wikipedia
Sphingosine kinase 1 is an enzyme that in humans is encoded by the SPHK1 gene. [5] [6] Sphingosine kinase 1 phosphorylates sphingosine to sphingosine-1-phosphate (S1P). SK1 is …
SPHK1 Gene - GeneCards | SPHK1 Protein | SPHK1 Antibody
2024年12月25日 · SPHK1 (Sphingosine Kinase 1) is a Protein Coding gene. Diseases associated with SPHK1 include Renal Fibrosis and Glioblastoma. Among its related pathways are …
Sphingosine kinase - Wikipedia
Sphingosine kinase (SphK) is a conserved lipid kinase that catalyzes formation sphingosine-1-phosphate (S1P) from the precursor sphingolipid sphingosine. Sphingolipid metabolites, such …
The Tumorigenic Effect of Sphingosine Kinase 1 and Its Potential ...
Sphingosine kinase 1 (SPHK1) regulates cell proliferation and survival by converting sphingosine to the signaling mediator sphingosine 1-phosphate (S1P). SPHK1 is widely overexpressed in …
Sphingosine kinase 1 promotes tumor immune evasion by
2022年9月1日 · We have elucidated an emerging functionality of SPHK1, identified SPHK1-mediated immunosuppression established by transcriptional regulation of PD-L1 in malignant …
The emerging roles of sphingosine 1-phosphate and SphK1 in …
2024年2月28日 · Our team overviewed SphK1 expression among different cancers, several resistance processes, S1P metabolism, S1P transport, S1P signaling, and SphKs inhibitors, …
SPHK1 sphingosine kinase 1 [ Homo sapiens (human) ]
2024年12月10日 · Title: SphK1 deficiency ameliorates the development of atherosclerosis by inhibiting the S1P/S1PR3/Rhoa/ROCK pathway. Interference with sphingosine kinase-1 …
Sphk1/S1P pathway promotes blood-brain barrier breakdown …
2024年12月23日 · Pharmacological inhibition of Sphk1 with PF543 attenuates BBB leakage, reduces hematoma volume, and improves neurological outcomes in mice. At the molecular …
8877 - Gene ResultSPHK1 sphingosine kinase 1 [ (human)]
Sphk1 plays an important role in the malignant transformation of breast epithelial cells and modulates breast cancer metastasis through the regulation of Ecadherin expression. SPHK1 is …
Therapeutic potential of targeting sphingosine kinases and …
2016年7月27日 · Sphingosine kinases (SPHKs) are the enzymes that catalyze the conversion of sphingosine to S1P. There are two isoforms, SPHK1 and SPHK2, which are encoded by …