Genomic findings in schizophrenia and their implications
2023年10月18日 · Genetic findings have revealed the nature of schizophrenia’s close relationship to other conditions, particularly BD and childhood NDDs and provided an explanation for how common risk alleles...
Genetics of Schizophrenia: Overview of Methods, Findings and ...
Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia.
Schizophrenia genetics complements its mechanistic …
Refinement of genetic variants within the major histocompatibility complex reveals three distinct genetic influences on schizophrenia risk and sheds light on the disease’s neurobiology. The rationale behind most genetic studies of psychiatric disease is to provide a causal mechanistic basis for the development of effective therapies 1 , 2 .
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
2022年4月8日 · The Schizophrenia Exome Sequencing Meta-Analysis (SCHEMA) consortium identified 32 genes with damaging ultra-rare mutations associated with schizophrenia (false discovery rate (FDR) < 0.05 ...
Genomic findings in schizophrenia and their implications - PMC
Genetic findings have revealed the nature of schizophrenia’s close relationship to other conditions, particularly BD and childhood NDDs and provided an explanation for how common risk alleles persist in the population in the face of reduced fecundity.
Schizophrenia’s strongest known genetic risk deconstructed
2016年1月27日 · The site in Chromosome 6 harboring the gene C4 towers far above other risk-associated areas on schizophrenia’s genomic “skyline,” marking its strongest known genetic influence. The new study is the first to explain how specific gene versions work biologically to confer schizophrenia risk.
Schizophrenia genomics: genetic complexity and functional …
2024年7月19日 · In this Review, we describe what we now know about the genetics of schizophrenia and consider the neurobiological implications of this information.
Single-cell multi-cohort dissection of the schizophrenia ... - Science
Schizophrenia population genomics has identified strong germline genetic associations for this highly heritable disorder, and molecular investigation of postmortem brain samples has yielded evidence of transcriptomic and epigenomic alterations associated with this disease.
Genetic modifiers and subtypes in schizophrenia: Investigations …
Schizophrenia is a genetically and clinically heterogeneous disorder. Genetic risk factors for the disorder may differ between the sexes or between multiply affected families compared to cases with no family history. Additionally, limited data support a genetic basis for variation in onset and severity, but specific loci have not been identified. We …
Chromosomal Abnormalities and Schizophrenia - PMC
Schizophrenia is a common and serious psychiatric illness with strong evidence for genetic causation, but no specific loci yet identified. Chromosomal abnormalities associated with schizophrenia may help to understand the genetic complexity of the illness.