Sal-like protein 4 (SALL4) is a transcription factor encoded by a member of the Spalt-like (SALL) gene family, SALL4. [5][6] The SALL genes were identified based on their sequence homology to Spalt, which is a homeotic gene originally cloned in Drosophila melanogaster that is important for terminal trunk structure formation in embryogenesis and ...

After birth, SALL4 expression is down-regulated and absent in most adult tissues. However, SALL4 is re-expressed in various cancers. This review summarizes our current knowledge about the structure and expression patterns of SALL4, its role in stem and cancer cells, and the existing understanding of its molecular functions. 1.1.

SALL4 is a protein made by germ cells and by tumors that arise from germ cells, including seminoma, embryonal carcinoma, and yolk sac tumor.

2024年12月25日 · SALL4 (Spalt Like Transcription Factor 4) is a Protein Coding gene. Diseases associated with SALL4 include Duane-Radial Ray Syndrome and Ivic Syndrome. Among its related pathways are PIP3 activates AKT signaling and …

Restored SALL4 expression in adult tissues promotes cell proliferation, survival, invasion, migration, angiogenesis, and stemness and inhibits apoptosis through the regulation of its targeted genes in a variety of human cancers. This review discusses the most recent advances of SALL4 in tumor development, progression, and therapy resistance.

Spalt-Like Transcription Factor 4 (SALL4), a member of the SALL family, is a regulator of embryonic stem cells that plays a crucial role in cell renewal and proliferation. SALL4 expression starts as soon as two-cell stage.

A SALL4 zinc finger missense mutation predicted to result in increased DNA binding affinity is associated with cranial midline defects and mild features of Okihiro syndrome.

2022年2月12日 · SALL4 overexpression promotes proliferation, development, invasion, and migration in cancers through activation of the Wnt/β-catenin, PI3K/AKT, and Notch signaling pathways; expression of mitochondrial oxidative phosphorylation genes; and inhibition of the expression of the Bcl-2 family, caspase-related proteins, and death receptors.

2013年6月13日 · The oncofetal gene SALL4, a marker of a subtype of hepatocellular carcinoma with progenitor-like features, is associated with a poor prognosis and is a potential target for treatment.

2018年1月3日 · SALL4 is one of four human homologues (SALL1, 2, 3, and 4) of the Drosophila region-specific homeotic gene spalt (sal) [1, 2, 3, 4]. SALL4 encodes multiple Cys2His2 zinc finger (C2H2-ZF) domain-containing transcription factor that either activates or represses gene transcription depending on cell context.