Synaptosomal-Associated Protein, 25kDa (SNAP-25) is a Target Soluble NSF (N-ethylmaleimide-sensitive factor) Attachment Protein Receptor protein encoded by the SNAP25 gene found on chromosome 20p12.2 in humans.

SNAP-25 is a component of the SNARE complex, which is central to synaptic vesicle exocytosis, and, by directly interacting with different calcium channels subunits, it negatively modulates neuronal voltage-gated calcium channels, thus regulating intracellular calcium dynamics.

2019年11月10日 · Here, we review the SNAP-25 protein sub-family, which includes both the Q b and Q c SNARE-domains within a single protein. In vertebrates, this sub-family consists of SNAP-25, SNAP-23, SNAP-29 and SNAP-47, named for their apparent molecular weights.

SNAP-25 is plasma membrane protein which, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, ...

2024年12月25日 · SNAP25 (Synaptosome Associated Protein 25) is a Protein Coding gene. Diseases associated with SNAP25 include Myasthenic Syndrome, Congenital, 18 and Presynaptic Congenital Myasthenic Syndromes. Among its related pathways are Neurotransmitter release cycle and Uptake and actions of bacterial toxins.

2025年2月8日 · Clinical resource with information about SNAP25, Common genetic variants associated with cognitive performance identified using the proxy-phenotype method., Congenital myasthenic syndrome 18, Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality., and available tests.

2019年11月10日 · SNAP-25 is the founding member of a sub-family of SNARE-proteins, whose members are mostly localized to different parts of the post-Golgi secretory pathway. Here, we review the SNAP-25 protein sub-family, which in vertebrates consist of SNAP-25, SNAP-23, SNAP-29 and SNAP-47 (Fig. 2 A).