SFRP4 is a hub gene in a Type 2 Diabetes-associated gene coexpression module in human islets, and reduces glucose-induced insulin secretion through decreased β-cell exocytosis. Expression and release of SFRP4 from islets is enhanced by interleukin-1β .

2024年12月25日 · SFRP4 (Secreted Frizzled Related Protein 4) is a Protein Coding gene. Diseases associated with SFRP4 include Pyle Disease and Osteomalacia. Among its related pathways are ncRNAs involved in Wnt signaling in hepatocellular carcinoma and Alzheimer's disease and miRNA effects.

2022年9月27日 · SFRP4 + stromal cells promote the regeneration of endometrial epithelial glands and full thickness endometrial injury through IGF1 signaling pathway in vivo

In this review, we provide a brief introduction to sFRP4, an update of the pathways it's involved, its various physiological actions that are reported to contribute to diseases, outlining the importance of its wider research and specific modulation by pharmacologic interventions.

sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the suppression of the Wnt signal through upregulated sFRP4.

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling.

The SFRP4 gene provides instructions for making a protein called secreted frizzled-related protein 4 (SFRP4). This protein blocks (inhibits) a process called Wnt signaling.

Secreted frizzled-related protein 4 (sFRP4) is a member of the secreted frizzled-related protein family of Wnt inhibitors that bind directly to Wnt and antagonize both canonical and noncanonical Wnt pathways. 12 We have previously shown antiproliferative and proapoptotic roles for sFRP4 during normal homeostasis in tissues such as ovary, corpus ...

SFRP4 is the largest member of SFRP family and is implicated in many diseases including obesity, type 2 diabetes (T2D), and cancer. SFRP4 acts as a biomarker for T2D and was expressed several years before clinical diagnosis of disease.

2025年2月8日 · Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling.

Secreted frizzled-related proteins (SFRPs) are mainly known for their role as extracellular modulators and tumor suppressors that downregulate Wnt signaling.

2022年9月27日 · We identified an SFRP4 + stromal cell subpopulation that was highly enriched in the regenerative stage of the human endometria during the menstrual cycle, and the SFRP4 + stromal cells could significantly enhance the proliferation of human endometrial epithelial organoid in vitro, and promote the regeneration of endometrial epithelial glands ...

2019年7月13日 · SFRP4 acts as a biomarker for T2D and was expressed several years before clinical diagnosis of disease. This review mainly focusses on the role of SFRP4 in obesity and how it can lead to β-cell failure and ultimately to T2D.

2016年4月27日 · sFRP4 is an extracellular Wnt antagonist that fine-tunes its signal activity by direct binding to Wnts. Bone fragility under oxidative stress by diabetes and aging is partly related to the...

2016年7月6日 · Secreted frizzled-related protein 4 (SFRP4) is highly expressed in the islets, and its levels are increased several years before diabetes diagnosis (1). We report here on the systemic levels of SFRP4 and its association with insulin resistance and β-cell dysfunction.

SFRP4. Official Name: secreted frizzled related protein 4 [Source:HGNC Symbol;Acc:HGNC:10778] Ensembl ID: ENSG00000106483. Bio databases IDs: NCBI: 6424 Ensembl: ENSG00000106483: Aliases: secreted frizzled related protein 4 : Pathways. WNT/β-catenin Signaling; Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis;

2018年5月1日 · In this review, we provide a brief introduction to sFRP4, an update of the pathways it's involved, its various physiological actions that are reported to contribute to diseases, outlining the importance of its wider research and specific …

2017年5月23日 · This study investigated molecular signals essential to sustain cancer stem cells (CSCs) and assessed their activity in the presence of secreted frizzled-related protein 4 (sFRP4) alone or in combination with chemotherapeutic drugs.

2009年4月1日 · SFRP4 protein is comprised of 346 amino acids with a predicted molecular weight of 39.9 kDa and an actual molecular weight of approximately 50-55 kDa. SFRP4 belongs to a family of five SFRPs; these proteins fold into two independent domains. The N-terminus contains a secretion signal peptide followed by a ~120 amino acid cysteine-rich domain (CRD).

2017年5月23日 · SFRP4 is a known Wnt antagonist, and is also pro-apoptotic and anti-angiogenic. Additionally, sFRP4 has been demonstrated to confer chemo-sensitization and improve chemotherapeutic efficacy....