SETD2 Neurodevelopmental Disorders - GeneReviews® - NCBI Bookshelf
2021年12月30日 · SETD2 neurodevelopmental disorder (SETD2-NDD) with macrocephaly/overgrowth, the most common phenotype, can also include developmental …
SETD2 Gene - GeneCards | SETD2 Protein | SETD2 Antibody
2024年12月25日 · SETD2 (SET Domain Containing 2, Histone Lysine Methyltransferase) is a Protein Coding gene. Diseases associated with SETD2 include Intellectual Developmental …
SETD2: a complex role in blood malignancy | Blood | American …
2017年12月14日 · SETD2, the sole known HMT to create the histone H3 lysine 36 trimethyl (H3K36me3) modification through this histone change, mediates multiple molecular processes …
SETD2 loss-of-function uniquely sensitizes cells to epigenetic ...
2025年2月5日 · SETD2 is the sole epigenetic factor responsible for catalyzing histone 3, lysine 36, tri-methylation (H3K36me3) in mammals. Its role in regulating cellular processes such as …
Pan-cancer analysis of SETD2 mutation and its association with …
2021年6月14日 · Histone methyltransferase SETD2 plays a critical role in maintaining genomic integrity and stability. Here, we investigated the characteristics of SETD2 somatic mutation in …
SETD2: from chromatin modifier to multipronged regulator of
2022年6月6日 · SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well …
SETD2 regulates the maternal epigenome, genomic imprinting and ... - Nature
2019年4月29日 · In this study, we show that SETD2 is a key player that instructs the proper establishment of the mammalian oocyte epigenome. Importantly, maternal deficiency in …
SETD2 Neurodevelopmental Disorders - PubMed
2022年9月22日 · Clinical description: SETD2 neurodevelopmental disorders (SETD2-NDDs) represent a clinical spectrum that most commonly includes various degrees of intellectual …
SETD2: from chromatin modifier to multipronged regulator of
2022年6月6日 · SETD2 (Set2 in yeast) is best known for associating with the transcription machinery and methylating histone H3 on lysine 36 (H3K36) during transcription. This well …
SETD2: an epigenetic modifier with tumor suppressor functionality
2016年8月2日 · Recently, the first drugs have been reported that specifically target SETD2-negative tumors. In this review we discuss the studies on the associated protein, Set domain …
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