2024年12月25日 · RAD23B (RAD23 Homolog B, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23B include Xeroderma Pigmentosum Group C and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA repair pathways, full network.

2025年3月8日 · Title: Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis. Upregulation of GRIM-19 augments the sensitivity of prostate cancer cells to docetaxel by targeting Rad23b.

2009年4月5日 · Rad23, which was originally identified as an important factor involved in the recognition of DNA lesions, also plays a central role in targeting ubiquitylated proteins for proteasomal degradation, an activity that it shares with …

2023年6月1日 · The distinct phenotypes of RAD23A and RAD23B are most likely due to the higher expression levels of RAD23B [41] or different spatiotemporal expression of the two homologs in mice embryonic development.

Knockdown of circ‐RAD23B inhibited NSCLC cell malignant behaviors, including proliferation, migration, invasion, angiogenesis and cell cycle progression, and also blocked tumor growth in vivo. Circ‐RAD23B conducted these effects by regulating the miR‐142‐3p/MAP4K3 axis.

RAD23A and RAD23B, the human orthologs of yeast rad23, play distinct roles in nucleotide excision DNA repair (NER) and in the ubiquitin-proteasome system (UPS). NER is a genome maintenance pathway responsible for repair of bulky DNA lesions, and UPS performs protein degradation in diverse cellular processes, including DNA repair (summary by ...

We report here a mode of spatial regulation of RAD23B that controls XPC stability and DNA damage repair. We first identified that RAD23B was able to directly associate with PAQR3, a newly-discovered tumor suppressor implicated in many types of human cancers.

2021年9月28日 · RAD23B, human homologue of yeast UV excision repair protein, may be a histological marker for colorectal cancer progression. The elevated expression levels of RAD23B correlates with poor patient outcome in advanced colorectal cancer.

2025年2月8日 · Gene ID: 19359, updated on 8-Feb-2025. Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and RNA polymerase II-specific DNA-binding transcription factor binding activity. Acts upstream of or within DNA damage response; cellular response to interleukin-7; and spermatogenesis. Located in cytoplasm and nucleus.

Orthologous to human RAD23B (RAD23 homolog B, nucleotide excision repair protein). [provided by Alliance of Genome Resources, Feb 2025] UV excision repair protein RAD23 homolog B, RAD23b homolog. Predicted to enable several functions, including DNA damage sensor activity; proteasome binding activity; and ubiquitin binding activity.