2024年12月25日 · PRKACA (Protein Kinase CAMP-Activated Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PRKACA include Pigmented Nodular …

PRKACA mutations are highly specific for cortisol over-secretion, while they are absent or very rare in the context of other adrenal diseases. Patients carrying these somatic mutations are …

2016年2月15日 · This article focuses on the discovery, structure, cellular location and physiological effects of the catalytic subunit alpha of protein kinase A (encoded by the gene …

2015年5月20日 · In this review, we summarize the current understanding of the involvement of PRKACA in adrenocortical tumorigenesis, and our understanding of PKA's role in …

PRKACA and PRKACB encode the dominant PKAc isoforms Cα and Cβ, respectively. There are at least two splice variants of PRKACA (Cα1 and Cα2; Cα3 has been reported but remains to …

In this review, we summarize the current understanding of the involvement of PRKACA in adrenocortical tumorigenesis, and our understanding of PKA's role in adrenocortical lesions. …

These results implicate a recurrent gain-of-function mutation in PRKACA in cortisol-producing adrenal adenomas. This was the most frequently mutated gene in our cohort. Mutant PRKACA …

2024年9月19日 · Clinical resource with information about PRKACA, Cardioacrofacial dysplasia 1, Pigmented nodular adrenocortical disease, primary, 4, and available tests. There are links to …

2025年2月8日 · Enables cAMP-dependent protein kinase activity; protein kinase binding activity; and small GTPase binding activity. Involved in several processes, including peptidyl-serine …

2025年1月20日 · Mechanistically, Nsun2 specifically methylates PKA catalytic subunit alpha (PRKACA) mRNA, which substantially promotes PRKACA translation in a YBX1-dependent …