2024年12月25日 · PLIN2 (Perilipin 2) is a Protein Coding gene. Diseases associated with PLIN2 include Sebaceous Adenocarcinoma and Meibomian Cyst. Among its related pathways are Epigenetic regulation by WDR5-containing histone modifying complexes and Selective autophagy. An important paralog of this gene is PLIN3.

2022年5月25日 · Upon exit from pluripotency, lipid droplet (LD)-associated protein Plin2 is recognized by Hsc70 and degraded via chaperone-mediated autophagy to facilitate LD mobilization.

2023年5月8日 · Mechanistically, the gradual upregulation of PLIN2 could induce the accumulation of ectopic lipid droplets and triacylglycerols in flight muscles during the ageing process.

脂蛋白 2： 由该基因编码的蛋白质属于 perilipin 家族，其成员覆盖细胞内脂质储存液滴。这种蛋白质与脂质球表面膜物质有关，可能参与脂肪组织的发育和维持。然而，它并不像以前认为的那样仅限于脂肪细胞，而是存在于广泛的培养细胞系中，包括成纤维细胞、内皮细胞和上皮细胞以及组 …

2017年7月3日 · Of the corresponding gene products, PLIN2 is the only constitutive and ubiquitously expressed lipid droplet protein that has been used as a protein marker for lipid droplets. We and others reported that plin2-/-mice have an ∼60% reduction in TG content, and are protected against fatty liver disease. Here we show that PLIN2 overexpression ...

Overexpression or suppression of PLIN2 can enhance or inhibit tumor cell migration, invasion, and vascular permeability in vitro, which is also confirmed in vivo. Mechanistically, it is demonstrated that PLIN2 boosts HIF1α/SPP1 signaling in macrophages, thereby exerting pro-tumor functions.

2023年9月25日 · Despite the key roles of perilipin-2 (PLIN2) in governing lipid droplet (LD) metabolism, the mechanisms that regulate PLIN2 levels remain incompletely understood. Here, we leverage a set of genome-edited human PLIN2 reporter cell lines in a series of CRISPR-Cas9 loss-of-function screens, identifying …

2025年2月7日 · PLIN2, a marker of macrophage LDs, is essential for cell survival under hypoxia and its expression can be stimulated by HIF1α in post-ischemic brain injury. However, the relationship between hypoxia and LDs requires further investigation.

Perilipin2 (PLIN2)，又称脂肪分化相关蛋白(ADRP)，参与协助中性脂质在脂滴内的储存。有研究报道，PLIN2在胃癌组织中呈现出显著的过表达。然而，对于PLIN2如何通过脂质代谢失衡来诱发胃部肿瘤的具体机制目前仍未清晰。

重要的是，plin2缺乏症通过增强的自噬作用降低了野生型小鼠胚胎成纤维细胞（mef）中的细胞tg含量，但不会影响缺少自噬功能的atg7-/-mef中的细胞tg含量。