2024年12月25日 · PDGFB (Platelet Derived Growth Factor Subunit B) is a Protein Coding gene. Diseases associated with PDGFB include Dermatofibrosarcoma Protuberans and Basal Ganglia Calcification, Idiopathic, 5.

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. [5][6]

血小板源性生长因子（platelet-derived growth factor，PDGF）是一种可刺激结缔组织增生的常见肽类调节因子，由骨髓巨噬细胞合成，贮存于血小板Q颗粒中。PDGF是碱性糖蛋白，分子量为28～35kD，是由两亚基（A链和B链）通过二硫键结合而成的两条多肽链的二聚体。PDGF是一种重要的促细胞分裂剂，能刺激血管 ...

上一篇推文中，我们介绍了血管内皮生长因子VEGF家族。血小板源性生长因子PDGF家族与VEGF家族是血管生长因子的两个主要家族，进化关系近。 一、 PDGF家族成员及受体成员 目前已知有四种PDGF基因：PDGF-A、PDGF-B、P…

血小板衍生生长因子亚基 B： 该基因编码由血小板衍生生长因子 (PDGF) 和血管内皮生长因子 (VEGF) 组成的蛋白质家族成员。编码的前原蛋白经过蛋白水解处理生成血小板衍生生长因子亚基 B，它可以与相关的血小板衍生生长因子亚基 A 同二聚化或异二聚化。这些蛋白质结合并激活 PDGF 受体酪氨酸激酶 ...

2025年3月8日 · Gene target information for PDGFB - platelet derived growth factor subunit B (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

The PDGFB gene provides instructions for making one version (isoform) of the platelet derived growth factor (PDGF) protein. This protein is involved in many cellular processes, including cell growth and division (proliferation), maturation (differentiation), and movement.

2025年1月11日 · Clinical resource with information about PDGFB, Basal ganglia calcification, idiopathic, 5, Familial meningioma, Idiopathic basal ganglia calcification 1, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2025年1月23日 · PDGFB, which is involved in various immune responses, influences the malignant characteristics of various cancer types and controls immune cell infiltration. We confirmed that PDGFB positively correlated with CD8 and PDL1 expression in lower grade glioma.

这个基因编码一个蛋白质家族成员，该家族包括血小板来源的生长因子（PDGF）和血管内皮生长因子（VEGF）。编码的前原蛋白在蛋白水解过程中被加工，生成血小板来源的生长因子B亚基，它可以同源二聚化，或者与相关的血小板来源的生长因子A亚基异源二聚化。这些蛋白质结合并激活血小板来源的 ...