2019年2月12日 · In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis.

2024年8月10日 · We demonstrate that PAK4 promotes insulin resistance by phosphorylating AMPKα2 at Ser491, thereby inhibiting AMPK activity. We additionally show that skeletal muscle-specific expression of a...

2024年12月25日 · PAK4 (P21 (RAC1) Activated Kinase 4) is a Protein Coding gene. Diseases associated with PAK4 include Prostate Cancer and Autosomal Recessive Nonsyndromic Deafness 108. Among its related pathways are Integrin Pathway and …

PAK4 facilitates the binding of TRADD to TNFR1 while inhibiting apoptosis under TNF-α inducement and NF-κB mediation. Moreover, PAK4 activates both PI3K/Akt and MEK/ERK pathways, thus having an effect on NF-κB so as to inhibit apoptosis. PAK4 promotes oncogenic transformation (bottom left).

2023年8月17日 · Here, we report that oncoprotein p21-activated kinase 4 (PAK4) is an NCoR1 kinase. Specifically, PAK4 phosphorylates NCoR1 at T1619/T2124, resulting in an increase in its nuclear...

2025年2月8日 · PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton.

2021年9月1日 · PAK4 overexpression is a predictive biomarker for tumor development and resistance to cancer treatments. PAK4 is also a regulator of the anti-tumor immune response. Targeting PAK4 would regulate immune cells response to anti-PD-1/anti-PD-L1 immune checkpoint inhibition therapy.

We found that the expression of PAK4 in NSCLC tissues was higher than that in the normal lung tissues, suggesting that PAK4 could be a predictive marker for the therapy and prognosis of NSCLC. To our knowledge, this is the first time to demonstrate the prognostic role of …

2023年1月1日 · Ongoing findings explain how PAK4 is involved in cancer progression, promoting cancer cell growth, survival, and metastasis with the corresponding activation and signaling schemes.

In this article, we review the PAK4 signaling pathways involved in prostate cancer, Parkinson’s disease, and melanogenesis, focusing in particular on the PAK4-CREB axis. Subject terms: Cell signalling, Experimental models of disease, Cell death in the nervous system.