PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy. Keywords: PTPN2, inflammation, tumor immunotherapy. 1. Introduction.

2025年2月12日 · PTPN2 (protein tyrosine phosphatase nonreceptor type 2) is an important member of the protein tyrosine phosphatase (PTP) family. It plays a crucial role in dephosphorylating tyrosine-phosphorylated proteins and modulating critical signaling pathways associated with T-cell receptors, IL-2, IFNγ, and various cytokines.

High PTPN2 Expression Was Independent Predictive Factors for Poor Outcomes in Pancreatic Adenocarcinoma Patients. Recently, PTPN2 has been identified as a potential target for cancer treatment.

2024年12月25日 · PTPN2 (Protein Tyrosine Phosphatase Non-Receptor Type 2) is a Protein Coding gene. Diseases associated with PTPN2 include Oligoarticular Juvenile Idiopathic Arthritis and Rheumatoid Factor-Negative Polyarticular Juvenile Idiopathic Arthritis.

2022年9月2日 · PTPN2 exerts synergistic anti-inflammatory effects in various inflammatory cells and regulates the developmental differentiation of immune cells. The diversity of PTPN2 effects in different types of tumors makes it a potential target for tumor immunotherapy.

2023年10月4日 · Here we present the discovery and characterization of ABBV-CLS-484 (AC484), a first-in-class, orally bioavailable, potent PTPN2 and PTPN1 active-site inhibitor. AC484 treatment in vitro...

2024年5月29日 · Genetic deletion of PTPN2 in either tumor cells or host immune cells promotes the anti-tumor immunity. In addition, PTPN2 inhibitors, alone or in combination with anti-PD1 therapy, significantly reduced tumor growth and enhanced survival in several subcutaneous tumour models.

2017年7月19日 · In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the ...

We show that, for the first time, protein-tyrosine phosphatase non-receptor type 2 (PTPN2) regulates the KRAS plasma membrane association and plays an important role in KRAS-dependent cancer cell proliferation and survival.

Protein tyrosine phosphatase non-receptor type 2 and protein tyrosine phosphatase non-receptor type 1 (PTPN2/N1) are closely related members of the protein tyrosine phosphatase family that act as negative regulators of multiple signaling pathways including cytokine signaling in immune cells. 1,2 PTPN2 and PTPN1 target signaling molecules within ...