PRDM1/BLIMP-1 is a master transcription factor regulating downstream cytokines. It is activated by TLRs and IRF-4, and is crucial in T cell, B cell, and myeloid lineage cell differentiations.

2024年12月25日 · PRDM1 (PR/SET Domain 1) is a Protein Coding gene. Diseases associated with PRDM1 include Myeloma, Multiple and Plasmablastic Lymphoma. Among its related …

PRDM1 is a prognostic marker in Kidney renal clear cell carcinoma Cancer specificity i Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group …

The Prdm1-iCre (Blimp1-iCre) mouse is generated by integrating the P2A-iCre expression cassette into the stop codon of the mouse Prdm1 gene. Under the control of mouse Prdm1 …

2020年12月15日 · Background: PR domain zinc finger protein 1 (PRDM1) is a regulator of both B cell and T cell differentiation and plays a critical role in immunosuppression. Its role in tumor …

2024年11月5日 · Using CRISPR/Cas9 targeting, we have demonstrated that PRDM1 -deficient CAR T cells exhibit enhanced proliferative capacity, memory characteristics, and resilience …

2023年11月2日 · In NK-cells, deletion of PRDM1 has been shown to promote cell growth and survival in vitro, and its loss of function was commonly detected in NK-cell lymphomas. Here, …

2019年11月13日 · PRDM1 bound a large number of genes in the NK or T cell receptor signaling pathway, which are employed during NK cell activation. In addition, several genes encoding …

2024年1月18日 · Prdm1 facilitates the intercellular communication between liver group 1 ILCs and macrophages. The reciprocal crosstalk between group 1 ILCs and macrophages plays a …

Using Ncr1-drived conditional knockout mouse model, our study reveals the regulatory role of Prdm1 in shaping the composition and maturation of liver Type 1 ILCs. Notably, Prdm1 …