PRC2 - Wikipedia
PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb Repressive Complex …
Role of the Polycomb Repressive Complex 2 (PRC2) in …
PRC2 is involved in establishing and maintaining gene expression patterns and, in turn, cell fates. Activating and inactivating mutations in genes encoding PRC2 contribute to human cancers, …
The Polycomb complex PRC2 and its mark in life - Nature
2011年1月19日 · In mammals, two main Polycomb group complexes exist — Polycomb repressive complex 1 (PRC1) and 2 (PRC2). PRC1 compacts chromatin and catalyses the …
PRC2, Chromatin Regulation, and Human Disease: Insights From …
2022年6月21日 · Polycomb repressive complex 2 (PRC2) is a multisubunit histone-modifying enzyme complex that mediates methylation of histone H3 lysine 27 (H3K27). Trimethylated …
PRC2 - an overview | ScienceDirect Topics
PRC2 is a major chromatin-modifying complex that is key to this process. PRC2 can deposit one or more methyl groups on lysine 27 of histone H3 (H3K27me1, H3K27me2, and H3K27me3, …
PRC2: an epigenetic multiprotein complex with a key role in the ...
Polycomb Repressive Complex 2 (PRC2). PRC2 catalyzes the methylation of H3K27 through its enzymatic subunit EZH1 or EZH2. H3K27me3 correlates with gene silencing
Structure of the PRC2 complex and application to drug discovery
2017年4月17日 · The polycomb repressive complexes 2 (PRC2) complex catalyzes tri-methylation of histone H3 lysine 27 (H3K27), a repressive chromatin marker associated with …
Engaging chromatin: PRC2 structure meets function
2019年11月11日 · Polycomb repressive complex 2 (PRC2) is a key epigenetic multiprotein complex involved in the regulation of gene expression in metazoans.
Novel insights into the dynamic function of PRC2 in innate immunity
2024年11月26日 · PRC2 catalyzes methylation of histone H3 at lysine 27 (H3K27me3) and is known for maintaining eukaryote cell identity. Recent discoveries show that modulation of …
Polycomb repressive complex 2 (PRC2) pathway’s role in
2025年3月6日 · PRC2’s role extends beyond gene repression, as it contributes to metabolic reprogramming in tumors, regulating glycolysis and lipid synthesis to fuel cancer growth. …