Prostaglandin F2α (PGF2A) has multiple roles in the birth process in addition to its vital contractile role. Our previous study has demonstrated that PGF2A can modulate uterine activation proteins (UAPs) in cultured pregnant human myometrial smooth muscle cells (HMSMCs).

2021年1月15日 · Prostaglandin E2 (PGE2) and F2α (PGF2α) are the two most prominent prostanoids in parturition. They are involved in cervical ripening, membrane rupture, myometrial contraction and inflammation in gestational tissues.

2003年4月1日 · PGF 2α mediates its effects through a seven-transmembrane G-protein-coupled receptor (FP). The aim of this study was to examine the temporal expression, signaling, and role of FP receptor in the human endometrium.

2023年12月8日 · Activation of the FP receptor in the human myometrium by its endogenous agonist prostaglandin F 2α (PGF 2α) causes the elevation of intracellular calcium concentration and leads to contraction of...

Prostaglandin F 2α receptor (FP) is required for female reproductive function such as luteolysis and parturition. It has recently been implicated in blood pressure regulation, atherosclerosis and other inflammation-related disorders.

2023年5月9日 · Prostaglandin F 2α (PGF 2α), an endogenous arachidonic acid metabolite, regulates diverse physiological functions in many tissues and cell types through binding and activation of a...

2023年6月19日 · Prostaglandin F 2α (PGF 2α) is an important component for the physiology of female reproductive processes. In the literature, the data pertaining to the synthesis and action of PGF 2α in early embryonic bovine development are limited.

Prostaglandin E2 (PGE2) has been identified as a PG necessary for ovulation, but the ovulatory gonadotropin surge also increases PGF2α levels in primate periovulatory follicles. To better understand the role of PGF2α in ovulation, pathways utilized for PGF2α synthesis by the primate follicle were examined.

Prostaglandin F2-alpha (PGF-2 alpha) is a stable prostaglandin that stimulates the contraction of uterine and bronchial smooth muscle and produces vasoconstriction (tightening) in some blood vessels. As a pharmaceutical, the generic name of PGF-2 alpha is dinoprost.

2021年9月1日 · Although prostaglandins are important in the ovulation process, a precise role for prostaglandin F2α (PGF) has not been elucidated. This study aimed to evaluate the regulation of PGF receptor mRNA (PTGFR) in granulosa cells and …