PBRM1 is thought to be a tumor suppressor gene in many cancer subtypes largely due to the mutational pattern. [10] Most notably, mutations and copy number alterations in PBRM1 are …

2024年12月25日 · PBRM1 (Polybromo 1) is a Protein Coding gene. Diseases associated with PBRM1 include Clear Cell Renal Cell Carcinoma and Renal Cell Carcinoma, Nonpapillary. …

PBRM1 encodes the BAF180 protein, which is important in chromatin remodeling (Lu and Allis, 2017; Zhou et al., 2020). PBRM1 genes had approximately 5% mutational frequency in …

2020年3月16日 · Polybromo-1 (PBRM1) gene is a promising biomarker for immunotherapy in clear cell renal cell carcinoma. But to our knowledge, the frequency and clinical relevance of …

PBRM1, a subunit of the PBAF chromatin-remodeling complex, is involved in DNA damage repair. Herein, we aimed to decipher the molecular landscape of PBRM1 mutated (mut) BTCs and to …

2025年1月4日 · Title: Non‑small cell lung cancer carrying PBRM1 mutation suggests an immunologically cold phenotype leading to immunotherapy failure even with high TMB.

2020年5月1日 · In this study, we found that PBRM1 loss reduced IFNγ-STAT1 signaling in murine and human RCC cell lines, respectively, in a SWI/SNF complex dependent manner. PBRM1 …

2016年4月21日 · PBRM1 re-expression led to upregulation of genes involved in cellular adhesion, carbohydrate metabolism, apoptotic process and response to hypoxia, and a downregulation …

2019年2月26日 · Recent data suggested PBRM1 mutations may sensitize ccRCC and non RCC malignancies to ICB therapy. We queried the impact of PBRM1 loss on overall survival (OS) …

2021年6月1日 · Inactivation of Polybromo 1 (PBRM1), a specific subunit of the PBAF chromatin remodeling complex, occurs frequently in cancer, including 40% of clear cell renal cell …