Oncostatin-M specific receptor subunit beta also known as the Oncostatin M receptor (OSMR), is one of the receptor proteins for oncostatin M, that in humans is encoded by the OSMR gene. [5] [6] OSMR is a member of the type I cytokine receptor family.

2024年12月25日 · OSMR (Oncostatin M Receptor) is a Protein Coding gene. Diseases associated with OSMR include Amyloidosis, Primary Localized Cutaneous, 1 and Primary Cutaneous Amyloidosis. Among its related pathways are …

The OSMR gene provides instructions for making a protein called oncostatin M receptor beta subunit (OSMRβ). Learn about this gene and related health conditions.

2021年12月17日 · Here, we describe how heterocellular Oncostatin M (OSM) - Oncostatin M Receptor (OSMR) signalling reprograms fibroblasts, regulates tumour growth and metastasis.

2025年1月4日 · Title: Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.

2020年8月17日 · Nature Communications - The suppression of the receptor for oncostatin M (OSMR) can prevent glioblastoma cell growth. Here, the authors demonstrate a role for OSMR in modulating glioma stem...

2024年6月5日 · Using ectopic expression and knockdown approaches, we proved that OSMR directly regulates ITGAV and ITGB3 gene expression through STAT3 activation. Notably, targeting OSMR using anti-OSMR...

Heterocellular OSM-OSMR signalling reprograms fibroblasts to promote pancreatic cancer growth and metastasis. Oncostatin M Receptor-Targeted Antibodies Suppress STAT3 Signaling and Inhibit Ovarian Cancer Growth.

OSMR is a prognostic marker in Glioblastoma multiforme, Lung adenocarcinoma, Pancreatic adenocarcinoma

The oncostatin M (OSM) receptor (OSMR) shows frequent gene copy number gains and overexpression in cervical squamous cell carcinomas (SCCs), associated with adverse clinical outcomes. In SCC cells that overexpress OSMR, the major ligand OSM induces multiple pro-malignant effects, including invasion, …