2024年12月25日 · Complete information for NTN1 gene (Protein Coding), Netrin 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Netrin-1 is a protein that in humans is encoded by the NTN1 gene. [5] [6] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development. Mutations and loss of expression of netrin suggest ...

2024年11月27日 · Knockdown of netrin 1 (NTN1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1: PubMed

Results demonstrate that NTN1 is an important regulator of stemness and motility of glioblastoma cells. Furthermore, it deciphers a novel mechanism where NTN1 activates Notch signaling and subsequent stemness in invasive glioblastoma cells.

2021年1月27日 · However, the functional role of Neo1 or its ligands such as Ntn1 in HSC biology remains uncertain 1,42. Here, we identify Ntn1–Neo1 signalling as an important regulator of HSC quiescence.

2024年6月28日 · NTN1 was recently identified as a critical regulator of niche cell fitness during homeostasis, regeneration, and aging. Specifically, NTN1 was demonstrated to mediate niche rejuvenation, which was associated with a restoration in the self-renewal capacity of aged hematopoietic stem cells (HSCs) to youthful levels . Therefore, NTN1 can be a ...

2025年1月25日 · In SKCM, NTN1 was identified as an independent risk factor and demonstrated potential associations with multiple drugs. NTN1 exhibits substantial clinical utility as a prognostic marker and indicator of immune response across various tumor types. This comprehensive analysis provides insights into its potential implications in pan-cancer research.

关于 ntn1 Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:9,003,087-9,244,000 (from NCBI) This gene has 2 transcripts (splice variants), 270 orthologues, 27 paralogues and is associated with 2 phenotypes.

2024年9月15日 · Netrin-1(NTN1), a kind of secretory protein related to laminin, guides the direction of nerve growth by binding with its receptor, which can promote early synapse formation in addition to axon guidance function. NTN1 and its receptors (Unc5A-D) are well known to be involved in inflammation, tumor growth and axon regeneration [9,10].

神经素属于一层素相关分泌蛋白质家族。这个基因的功能尚未定义，但神经素被认为在发育过程中的轴突引导和细胞迁移中发挥作用。神经素的突变和表达丢失提示，神经素的变异可能涉及癌症发展。[由RefSeq，2008年7月提供]