Joshi Lab
The Joshi Lab uses intricate tumor models and advanced approaches to investigate immune cell interactions with developing tumors. NINJA mouse model → How effector T cells differentiate during cancer development and infection
TIME - Joshi Lab
Using engineered models, we have shown that the tumor draining-lymph node plays a critical role in the maintenance of a stem-like T cell (TSL) population over the course of tumor development, and that periodic migration of these TSL to the tumor is what maintains the pool of less differentiated T cells in the tumor (Connolly 2021).We have also shown that interactions …
Members - Joshi Lab
Support Staff. Aya Tal, PhD. – Associate Research Scientist; 2022 - 2023 – ARS, Yale University; Diane Trotta (Lab Manager) – Biotechnology Associate, Yale Flow Cytometry Facility
NINJA mouse — Joshi Lab
a Problem of leakiness. Developing thymocytes are very sensitive to the presence of their cognate antigen. As they transit through the medulla, thymocytes are exposed to many self antigens and the consequences of binding between the TCR and these self antigens can result in clonal deletion or development into a regulatory T cell fate (central tolerance).
TLS focus — Joshi Lab
We previously reported that TLS form in the KP lung adenocarcinoma model, and that these structures can recruit anti-tumor T cells and facilitate their interactions with tumor antigen-presenting dendritic cells (Joshi Immunity 2015). Moreover, depletion of regulatory T cells (Tregs) in TLS unleashed a potent anti-tumor immune response that led ...
Published stories — Joshi Lab
CD8 T cell responses are dynamic processes that are regulated by the signals that T cells receive from their environment. In the context of acute responses, these signals are delivered around the time of initial priming by the dendritic cell, but in chronic responses like cancer, T cells continue to receive signals from their environment and this can drive their terminal differentiation.
List of Publications — Joshi Lab
Joshi lab publications: Primary Literature: Mann JE, Lucca L, Austin MR, Merkin RD, Robert ME, Al Bawardy B, Raddassi K, Aizenbud L, Joshi NS, Hafler DA, Abraham C, Herold KC, Kluger HM. ScRNA-seq defines dynamic T-cell subsets in longitudinal colon and peripheral blood samples in immune checkpoint inhibitor-induced colitis.
Tolerance-Team — Joshi Lab
Joshi Lab Cancer Immunology. Home. Team Tolerance Investigating mechanisms and maintenance of T cell tolerance . Isolating lymphocytes from the liver. Models of tolerance. Once self-reactive CD8 and CD4 T cells exit into the periphery, they pose a danger of causing autoimmune disease if they become pathologic. ...
Our Funders - Joshi Lab
The Joshi lab has been generously supported over the years by several granting agencies and foundations. For those interested in making an impact on cancer research, we encourage you to visit their websites and learn more about their missions and ways to help.
Positions - Joshi Lab
Please email [email protected] with CV, cover letter, and three references if interested. We are accepting Yale BBS graduate students for rotations in the fall and spring semesters. We are no longer accepting Yale undergrads into the lab for the fall.