The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with ...

2024年12月25日 · NES (Nestin) is a Protein Coding gene. Diseases associated with NES include Embryonal Carcinoma and Periventricular Leukomalacia. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Neural Stem Cells and Lineage-specific Markers.

Nestin is an intermediate filament protein that is known as a neural stem/progenitor cell marker. It is expressed in undifferentiated central nervous system (CNS) cells during development, but also in normal adult CNS and in CNS tumor cells.

Nestin is a class VI intermediate filament protein that was originally described as a neuronal stem cell marker during central nervous system (CNS) development, and is currently widely used in that capacity. Nestin is also expressed in non-neuronal immature or progenitor cells in normal tissues.

Nestin is an intermediate filament protein expressed in radial glia and neuronal or glial progenitor cells during embryonic retinal development, and is reexpressed in adults after acute damage in the retina.

Nestin is best known for its expression in neuroepithelial progenitor cells in the CNS and peripheral nervous system starting from early development (Kawaguchi et al., 2001), but is in addition expressed in many other organs and cell types.

2024年7月1日 · In general, in nestin + stem cells and adult cells that re-express nestin after injury, nestin often directly affects cell biological behaviours such as proliferation, apoptosis and migration regulation in response to different tissue injuries.

2011年4月7日 · Neurons and glial cells in the developing brain arise from neural progenitor cells (NPCs). Nestin, an intermediate filament protein, is thought to be expressed exclusively by NPCs in the normal brain, and is replaced by the expression of proteins specific for neurons or glia in differentiated cells.

This review highlights the potential of nestin as a marker of multilineage stem/progenitor cells, and as a key factor in tissue development and tissue regeneration. The article discussed the current findings, limitations, and potential clinical implications or applications of nestin + cell …

Nestin is an intermediate filament protein transiently expressed in neural stem/progenitor cells. We previously demonstrated that outer root sheath (ORS) keratinocytes of adult hair follicles (HFs) in mice descend from nestin-expressing cells, despite being an epithelial cell lineage.