2024年12月25日 · NDN (Necdin, MAGE Family Member) is a Protein Coding gene. Diseases associated with NDN include Prader-Willi Syndrome and Schaaf-Yang Syndrome . Among its …

Necdin was originally found in 1991 as a hypothetical protein encoded by a neural differentiation‐specific gene transcript in murine embryonal carcinoma cells. Virtually all …

Necdin is a protein that is functionally similar to Rb, but structurally different. It is a smaller protein and does not undergo posttranslational modifications. Necdin plays a role in suppressing cell …

Necdin is a nuclear protein expressed in virtually all postmitotic neurons, and ectopic expression of this protein strongly suppresses the proliferation of NIH3T3 cells. Simian virus 40 large T …

2009年1月1日 · Necdin activates GnRH through Msx/Dlx-binding sites in the GnRH enhancer and promoter regions. If necdin activates through prevention of Msx repression, the characterized …

2011年10月27日 · Necdin expression has previously been shown to be down-regulated in a melanoma and a drug-resistant ovarian cancer cell line. Further analysis of Necdin expression …

2012年2月15日 · Moreover, we established that Necdin is a negative regulator of p53-mediated growth arrest induced by nutlin-3, suggesting that Necdin upregulation could contribute to the …

Necdin was originally found in 1991 as a hypothetical protein encoded by a neural differentiation-specific gene transcript in murine embryonal carcinoma cells. Virtually all postmitotic neurons …

2005年3月1日 · Necdin is a growth suppressor expressed predominantly in postmitotic neurons. The necdin gene is involved in the etiology of the genomic imprinting-associated …

One of these genes, NDN, encodes necdin, a protein that is important for neuronal differentiation and survival. Loss of Ndn in mice causes defects in the formation and function of the nervous …