2024年12月25日 · NDC80 (NDC80 Kinetochore Complex Component) is a Protein Coding gene. Diseases associated with NDC80 include Endometrial Adenosquamous Carcinoma and Endometrial Adenocarcinoma. Among its related pathways are EML4 and NUDC in mitotic spindle formation and Separation of Sister Chromatids.

2006年12月31日 · The Ndc80 complex is an essential core element of kinetochores, conserved from yeast to humans. It is a rod-like assembly of four proteins— Ndc80p (HEC1 in humans), Nuf2p, Spc24p and Spc25p.

2015年9月8日 · The Ndc80 complex, which mediates end-on attachment of spindle microtubules, is linked to centromeric chromatin in human cells by two inner kinetochore proteins, CENP-T and CENP-C.

The NDC80 (nuclear division cycle 80) complex takes part in chromosome segregation by forming an outer kinetochore and providing a platform for the interaction between chromosomes and microtubules, thus impacting the progression of mitosis and the cell cycle.

The NDC80 complex, which comprises four protein subunits, known as NDC80, NUF2, SPC24, and SPC25, is conserved from fungi to humans 2. The NDC80 complex is identified to have essential and critical roles in microtubule binding within the outer kinetochore.

The Ndc80 complex lies at the heart of the kinetochore, a large protein machine that accurately segregates chromosomes during cell division. The Ndc80 complex has structural roles in assembling the kinetochore, but also functions to congress chromosomes and to signal the spindle checkpoint.

2018年4月9日 · Presence of multiple copies of the microtubule-binding NDC80 complex is an evolutionary conserved feature of kinetochores, points of attachment of chromosomes to spindle microtubules. This may enable multivalent attachments to microtubules, with implications that remain unexplored.

2020年4月27日 · Spindle microtubules are attached end-on to kinetochores – large multi-protein complexes on chromosomes. This review focuses on the four-subunit NDC80 complex, one of the most important kinetochore elements that plays a major role in the attachment of assembling/disassembling microtubule ends to the chromosomes.

This review focuses on the four-subunit NDC80 complex, one of the most important kinetochore elements that plays a major role in the attachment of assembling/disassembling microtubule ends to the chromosomes.

2025年2月9日 · NDC80 Enhances Cisplatin-resistance in Triple-negative Breast Cancer. Chromosome oscillation promotes Aurora A-dependent Hec1 phosphorylation and mitotic fidelity. Mps1 dimerization and multisite interactions with Ndc80 complex enable responsive spindle assembly checkpoint signaling.