NLR family CARD domain-containing protein 4 is a protein that in humans is encoded by the NLRC4 gene. [5][6] The NLRC4 protein is highly conserved across mammalian species. It bears homology to the C. elegans Ced4 protein.

The NLRC4 inflammasomopathies are caused by gain-of-function mutations in the gene encoding the innate immune protein NLRC4. Mutant NLRC4 promotes spontaneous formation of the NLRC4 inflammasome, production of IL1 family cytokines …

In this review article, we provide an updated overview of NLRC4 inflammasomes, describing their composition, activation mechanisms and roles in both microbial infections and other disease conditions. The innate immune system is the body’s first line of defense against invasion by pathogens and is formed during long-term evolution of the germ line.

In this review, we endeavor to highlight recent breakthroughs related to NLRC4 inflammasome structure and activation, important in vivo work in infection and systemic inflammation, and the characterization of a spectrum of human NLRC4-associated autoinflammatory diseases.

2021年11月30日 · We explored whether NLRC4 knockdown alleviated inflammatory injury following intracerebral hemorrhage (ICH). Furthermore, we investigated whether NLRC4 inflammasome activation can be adjusted...

2024年1月4日 · Here we identify Bacillus thailandensis type III secretion system needle protein (Needle) as a potent trigger of the human NLR family apoptosis inhibitory protein (NAIP)/NLRC4 inflammasome...

2024年6月3日 · Epithelial human NLRC4 promotes patient survival and is associated to Type-I Interferon signaling and immune infiltration in cancer. Higher vertebrates have developed innate protective mechanisms that can detect stress-induced …

Upon NAIP/NLRC4 activation in the intestine, epithelial cell extrusion is triggered in addition to the canonical inflammasome outcomes of cytokine cleavage and pyroptosis. Human patients with auto-activating mutations in NLRC4 present with an …

2024年12月25日 · NLRC4 (NLR Family CARD Domain Containing 4) is a Protein Coding gene. Diseases associated with NLRC4 include Familial Cold Autoinflammatory Syndrome 4 and Autoinflammation With Infantile Enterocolitis .

2021年1月21日 · The NLR family apoptosis inhibitory proteins (NAIP)-NLR family caspase-associated recruitment domain-containing protein 4 (NLRC4) inflammasome is important for mounting an immune response against Gram-negative bacteria.