MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as …

2024年12月25日 · MYOD1 (Myogenic Differentiation 1) is a Protein Coding gene. Diseases associated with MYOD1 include Congenital Myopathy 17 and Myopathy, Centronuclear, 1. Among its related pathways are Signaling by TGFBR3 and Signaling by TGFB family members.

Myogenic differentiation antigen 1 (MyoD1) is a myogenic nuclear regulatory protein that is normally expressed during embryogenesis. Nuclear expression of MyoD1 is restricted to myoblasts of developing skeletal muscle tissue. MyoD1 is present in the majority of rhabdomyosarcomas.

2024年8月16日 · FUNCTION: Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Activates muscle-specific promoters. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).

MyoD1 Antibody recognizes endogenous levels of total MyoD1 protein. This antibody also detects a 142 kDa protein of unknown origin.

This test evaluates formalin-fixed, paraffin-embedded tumor or cytology slides from patients with solid tumors for specific gene mutations in the MYOD1 gene. Identifying a MYOD1 gene mutation may be of diagnostic and clinical management significance for spindle cell/sclerosing rhabdomyosarcoma.

2020年8月10日 · The MYOD1 gene, which is expressed exclusively in skeletal muscle, encodes a protein that belongs to a family of transcription factors essential for myogenic differentiation and repair (summary by Shukla et al., 2019).

2008年10月14日 · Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein.

2022年7月5日 · MyoD1, one of the MyoD family of myogenic helix-loop-helix transcription factors, combined with myogenin, plays a role in coordinating the differentiation of skeletal muscle. 1,2 MyoD1 is expressed in myoblasts before differentiation. 2 Anti-MyoD1 immunostaining identifies cells committed to myogenesis in their earliest phase. 2 In conjunction ...

Acts upstream of or within several processes, including myotube differentiation; regulation of RNA metabolic process; and skeletal muscle fiber adaptation. Located in euchromatin; myofibril; and nucleus. Part of transcription regulator complex.