2024年12月25日 · MUC17 (Mucin 17, Cell Surface Associated) is a Protein Coding gene. Diseases associated with MUC17 include Prostate Cancer and Adenocarcinoma. Among its …

Mucin-17 is a protein that in humans is encoded by the MUC17 gene. [3][4] Membrane mucins, such as MUC17, function in epithelial cells to provide cytoprotection, maintain luminal …

MUC17 is a transmembrane mucin that is expressed in the normal colon and small intestine [61, 70]. MUC17 is downregulated in inflammatory states such as ulcerative colitis and ischemic …

2009年5月1日 · Increased expression of MUC17, a recently identified membrane tethered mucin, has been reported in pancreatic tumor tissues and in cancer cell lines of pancreas and colon. …

MUC17 glycoprotein is a membrane-associated mucin that is mainly expressed in the digestive tract. It has been suggested that MUC17 expression is correlated with the malignancy …

Our results demonstrated that MUC17 has a central role in bile-induced PC progression, and in addition to MUC4, this isoform also can be used as a novel prognostic biomarker.

Learn about membrane mucin, MUC17 and how Amgen is investigating this therapeutic target in the treatment of gastric cancer.

2002年3月1日 · This novel mucin, designated MUC17, contains an extended, repetitive extracellular glycosylation domain and a carboxyl terminus with two EGF-like domains, a SEA …

Herein, we report the complete characterization of the MUC17 gene and its transcripts along with the deduced struc-tural organization of the protein. Our study shows that MUC17 is expressed …

2025年2月8日 · Gene ID: 140453, updated on 8-Feb-2025. The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein …

2019年7月1日 · Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable …

Gastric cancer is a heterogenous disease characterized by the overexpression and mis-localization of certain proteins, including MUC17, CLDN18.2, and RTKs (eg, FGFR2b, HER2), …

Herein, we report the complete characterization of the MUC17 gene and its transcripts along with the deduced structural organization of the protein. Our study shows that MUC17 is expressed …

A half-life extended (HLE), human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen …

The membrane-bound mucin MUC17 (mouse homolog Muc3) is highly expressed on the apical surface of intestinal epithelia and is thought to play a role in epithelial restitution and protection.

Analysis of The Cancer Genome Atlas database indicated that mucin-17 (MUC17) was more highly expressed in gastric cancer (GC) specimens, with favourable prognosis for patients. To …

Mucin-17 (MUC17, MUC3) is a transmembrane mucin encoded by the MUC17 gene located at the 7q22 region. MUC17 was more highly expressed in gastric cancer specimens. It has …

2006年8月18日 · Herein, we report the complete characterization of the MUC17 gene and its transcripts along with the deduced structural organization of the protein. Our study shows that …

MUC3A/B, MUC4, MUC11/12, MUC16, and MUC17, are part of large human MAMs found at the apex of epithelial cells of the secretory mucosa (Desseyn et al., 2008) and may to a lower …

2019年2月18日 · Gain- and loss-of-function assays showed that MUC17 inhibited the H. pylori -enhanced GC cell growth by preventing the translocation of H. pylori CagA into GC cells. …