Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [5] MMP-3 has an estimated molecular weight of 54 kDa. [6]

Matrix metalloproteinase 3 (MMP-3) is a member of the matrix metalloproteinase (MMP) family, which can degrade multiple ECM components. MMP-3 can activate multiple pro-MMPs and thus initiates the MMP-mediated degradation reactions.

Matrix metalloproteinase-3 (MMP-3) plays an important role in the pathology of rheumatoid arthritis (RA) and ankylosing spondylitis (AS). Measurement of active MMP-3 in clinical samples could provide information about progression of rheumatoid diseases, …

Serum level of MMP-3 appear to be an useful marker in the diagnosis of rheumatoid arthritis and also for the evaluation of prognosis of joint destruction and cartilage degradation. Increased MMP-3 in systemic lupus erythomatosis appears to be related to lupus nephritis.

2010年10月29日 · MMP-3 activity is regulated at three different levels: gene expression, proteolytic activation of the zymogen, and inhibition by the endogenous tissue inhibitors of metalloproteinase. A line of evidence indicates a role of MMP-3 in neurodegeneration.

2024年12月25日 · MMP3 (Matrix Metallopeptidase 3) is a Protein Coding gene. Diseases associated with MMP3 include Coronary Heart Disease 6 and Conjunctivochalasis. Among its related pathways are GPCR downstream signalling and Collagen chain trimerization. Gene Ontology (GO) annotations related to this gene include calcium ion binding and …

MMP-3 is associated with the occurrence and development of RA bone erosion, and its serum level and mRNA expression can be treated as important predictors of joint damage. new evidence that promoter polymorphisms in MMP3 are functional and may affect gene transcription with possible effects on craniofacial development leading to NSCL/P.