Mitochondrial DNA depletion syndrome (MDS or MDDS), or Alper's disease, is any of a group of autosomal recessive disorders that cause a significant drop in mitochondrial DNA in affected tissues. Symptoms can be any combination of myopathic, hepatopathic, or …

Mitochondrial DNA (mtDNA) depletion syndromes (MDS) are a genetically and clinically heterogeneous group of autosomal recessive disorders that are characterized by a severe reduction in mtDNA content leading to impaired energy production in affected tissues and organs.

Mitochondrial Depletion Syndrome (MDS) refers to a group of rare genetic disorders that limit the number of mitochondria inside of cells. Mitochondria are energy generators that power the function of cells in the body.

Mitochondrial disorders occur when mitochondria, the structures that produce energy for our cells, malfunction. This group of diseases is caused by a reduction of the mitochondrial DNA copy number in affected tissues in the absence of any mutations or rearrangements in the mitochondrial DNA itself.

Mitochondrial DNA (mtDNA) depletion syndromes (MDS) are a genetically and clinically heterogeneous group of autosomal recessive disorders that are characterized by a severe reduction in mtDNA content leading to impaired energy production in affected tissues and organs.

Mitochondrial DNA depletion syndrome 9 is caused by genetic mutations, also known as pathogenic variants. Genetic mutations can be hereditary, when parents pass them down to their children, or they may occur randomly when cells are dividing.

The mitochondrial DNA depletion syndromes (MDSs) are a clinically heterogeneous group of disorders with an autosomal recessive pattern of transmission that have onset in infancy or early childhood and are characterized by a reduced number …

This can cause a particular type of mitochondrial disease known as mitochondrial DNA depletion syndrome (MDDS). The term depletion refers to the markedly decreased amount of mitochondrial DNA found in muscle, liver and brain tissues in these disorders.

This can cause a particular type of mitochondrial disease known as mitochondrial DNA depletion syndrome (MDDS). The term depletion refers to the markedly decreased amount of mitochondrial DNA found in muscle, liver and brain tissues in these disorders.

Mitochondrial DNA Depletion Syndrome is a rare genetic disorder that affects the mitochondria, the energy-producing structures in cells. It is caused by mutations in genes involved in mitochondrial DNA replication and maintenance.