Minichromosome maintenance - Wikipedia
MCM2-7 is required for both DNA replication initiation and elongation; its regulation at each stage is a central feature of eukaryotic DNA replication. [3] During G1 phase, the two head-to-head …
MCM基因家族 - 知乎 - 知乎专栏
2022年4月19日 · mcm基因家族包括mcm2~7六个成员，广泛存在于包括从酵母到人类等真核生物中，具有调控细胞分裂的作用。 MCM名称来源为minichromosome mantenance，即微小染色 …
MCM2-7 complex is a novel druggable target for neuroendocrine …
2021年6月25日 · Inhibition of MCM2-7 by treatment with ciprofloxacin inhibits NEPC cell proliferation and migration in vitro, significantly delays NEPC tumor xenograft growth, and …
Cell：我国科学家领衔解析出人类MCM2-7复合物的三维结构，有 …
2023年1月15日 · 这项新研究的结果提供了人类起始前复合物---mcm2-7复合物---的高分辨率结构和机理信息，将来可用于开发靶向mcm2-7复合物的无毒抗癌药物。
Role of MCM2–7 protein phosphorylation in human cancer cells
2018年7月24日 · A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating …
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers …
2025年1月2日 · In eukaryotes, the ring-shaped hetero-hexameric protein, MCM2-7, represents the core of the replicative helicase. MCM2-7 loading, also known as pre-replicative complex …
MCM2-7 loading-dependent ORC release ensures genome-wide …
2024年8月24日 · Origin recognition complex (ORC)-dependent loading of the replicative helicase MCM2-7 onto replication origins in G1-phase forms the basis of replication fork establishment …
The MCM2-7 Complex: Roles beyond DNA Unwinding - MDPI
2024年3月6日 · The MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single …
The assembly of the MCM2-7 hetero-hexamer and its significance …
2023年6月28日 · The mini-chromosome maintenance proteins 2-7 (MCM2-7) hexamer is a protein complex that is key for eukaryotic DNA replication, which occurs only once per cell cycle. To …
The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic
2024年6月24日 · The MCM2-7 helicase plays a crucial role in unwinding the double-stranded DNA template during DNA replication. Recent studies indicate that the MCM2-7 helicase …