2024年12月25日 · MUC5B (Mucin 5B, Oligomeric Mucus/Gel-Forming) is a Protein Coding gene. Diseases associated with MUC5B include Interstitial Lung Disease 2 and Extrinsic Allergic Alveolitis . Among its related pathways are O-linked glycosylation of …

2018年12月18日 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a...

Idiopathic pulmonary fibrosis (IPF), a fatal disease that is a result of complex interactions between genetics and the environment, has limited treatment options. We have identified the MUC5B promoter polymorphism and other common genetic variants ...

2018年10月20日 · The common gain-of-function variant rs35705950 16 in the promoter of MUC5B, encoding mucin 5B, is the strongest genetic risk factor for idiopathic pulmonary fibrosis; it is observed in at least...

2022年11月25日 · Airway mucus is composed of two mucins: mucin 5B (MUC5B) and 5AC (MUC5AC). Together, they form a hydrogel that can be actively transported by cilia along the airway surface. In chronic respiratory diseases, abnormal expression of these mucins is directly implicated in dysfunctional mucus clearance.

2013年12月8日 · Here we show that mouse Muc5b (but not Muc5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc5ac...

2025年2月8日 · MUC5B is a novel prognostic biomarker for patients with non-small cell lung cancer (NSCLC)carrying EGFR mutations but not for patients with NSCLC carrying wild-type EGFR; MUC5B has recently been shown to be associated with idiopathic pulmonary fibrosis susceptibility and survival.

MUC5B, the major component, codes for a protein of 3570 amino acids, containing tandem repeats consisting of four superrepeats of 528 residues each (Desseyn et al. 1997), and is classified as a gel-forming mucin.

2019年11月22日 · The polymeric mucin MUC5B provides the structural and functional framework of respiratory mucus, conferring both viscoelastic and antimicrobial properties onto this vital protective barrier.

2018年12月18日 · Our findings suggest that mucociliary dysfunction might play a causative role in bleomycin-induced pulmonary fibrosis in mice overexpressing Muc5b, and that MUC5B in distal airspaces is a potential therapeutic target in humans with IPF.