MDCK (NBL-2) cells were isolated from normal kidney tissue from a normal, adult, female cocker spaniel. TMDCK (NBL-2) is used in toxicology and industrial biotechnology research.

Madin-Darby Canine Kidney (MDCK) is a continuous cell line of distal tubules of canine kidney widely used for different purposes, such as isolation of influenza viruses, production of flu vaccines, pathogenicity studies of bacterial strains, cytotoxicity tests.

The MDCK cell line provides a tractable model for studying protein trafficking, polarity and junctions (tight, adherens, desmosome and gap) in epithelial cells.

These results indicate that MDCK cells may be a useful tool for rapid membrane permeability screening. The goal of this work was to investigate the use of MDCK (Madin-Darby canine kidney) cells as a possible tool for assessing the membrane permeability properties of early drug discovery compounds.

MDCK.2 is an epithelial-like cell that was isolated from the distal renal tubule of a dog. This cell line was deposited by Y. Reid, E. Cedrone, E-Eckard-Amar, and can be used in toxicology research.

2015年11月13日 · Madin-Darby Canine Kidney Epithelial Cells (MDCK Line) Derived by S. H. Madin and N. B. Darby from the kidney tissue of an adult female cocker spaniel, the MDCK cell line originated in September 1958.

2024年11月27日 · Madin-Darby Canine Kidney (MDCK) cells are a widely used cell line in biological and medical research, particularly in studies involving virology, cell biology, and membrane transport. Here’s an overview of what is currently known about MDCK cells:

In mammalian epithelial cells such as MDCK cell lines, three evolutionarily conserved protein complexes play a key role in establishing and maintaining polarity along an apical–basal axis: the PAR3–PAR6–aPKC (PAR) complex, the SCRIB–LGL–DLG complex, and …

While MDCK cells provide significant advantages in vaccine production, the safety of vaccines derived from these cells is of paramount importance. MDCK cells were derived in the late 1950s from the kidney of a normal Cocker Spaniel.

Purchase high quality cryopreserved MDCK cells from ECACC for cell polarity, cell-cell adhesions, cell motility, as well as ADME/Tox cell permeability assays.