2024年12月25日 · LEF1 (Lymphoid Enhancer Binding Factor 1) is a Protein Coding gene. Diseases associated with LEF1 include Split Hand-Foot Malformation and Ectrodactyly And Ectodermal Dysplasia Without Cleft Lip/Palate. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular …

2021年6月21日 · Lymphoid enhancer binding factor 1 (LEF1) is a transcription factor for B and T cells and is involved in the Wnt / CTNNB1 pathway which regulates normal development of airway submucosal glands, mammary glands, teeth and adnexal structures (Nat Rev Immunol 2005;5:21, Development 1999;126:4441)

Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin signaling pathway, but can also modulate gene transcription independently.

2017年6月1日 · Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin signaling pathway, but can also modulate gene transcription independently.

Recently, the role of lymphocyte enhancer-binding factor 1 (LEF1) in CLL was elucidated being highly expressed and seeming to have a prognostic value. Our aim was to test the applicability of LEF1 as marker for CLL in a diagnostic setting.

2021年10月6日 · Using high-throughput chromosome-conformation-capture sequencing, we demonstrate that Tcf1/Lef1 are important for maintaining three-dimensional genome organization at multiple scales in CD8 + T...

2025年2月8日 · LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. The beta-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance.

2025年2月8日 · Data indicate Lef1 binds Pax3 & the complex binds to Lef1 promoter at Lef1 binding sites to enhance transcription of Lef1. In adult mouse brain, beta-catenin and LEF1 accumulate in the nuclei of neurons specifically in the thalamus.

2016年7月20日 · The mammalian TCF/LEF family comprises four nuclear factors designated TCF7, LEF1, TCF7L1, and TCF7L2 (also known as TCF1, LEF1, TCF3, and TCF4, respectively). The proteins display common structural features and are often expressed in overlapping patterns implying their redundancy.

2025年3月17日 · An in-depth study of the role of LEF1-AS1 in various aspects of cancer will contribute to basic research against LEF1-AS1-related targets as well as further tumor prevention, intervention, and clinical translational research. More than a quarter of global cancer cases and deaths occur in China, while 41.6% of new cancer cases and 49.3% of ...