Potassium voltage-gated channel, shaker-related subfamily, member 3, also known as KCNA3 or Kv1.3, is a protein that in humans is encoded by the KCNA3 gene. [5][6][7] Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints.

2024年6月1日 · Voltage-gated potassium channel 1.3 (Kv1.3) has emerged as a pivotal player in numerous biological processes and pathological conditions, sparking considerable interest as a potential therapeutic target across various diseases.

2022年7月4日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to...

ShK and Kv1.3 blocking polypeptides as potential therapeutic agents for neuroinflammatory diseases. ShK and Kv1.3 toxins might be used to treat multiple sclerosis, and other neuroinflammatory disorders via inhibiting Kv1.3 expressed in T …

2021年4月7日 · We show Kv1.3 channels regulate respiration through a non-conducting mechanism to generate reactive oxygen species which drive proliferation.

2017年3月1日 · Electrophysiology studies have implicated the potassium ion (K +) channel Kv1.3 as having a critical role in the regulation of chronically activated effector memory T (T EM) cell immune...

Introduction: Kv1.3 is the main voltage-gated potassium channel of leukocytes from both the innate and adaptive immune systems. Channel function is required for common processes such as Ca 2+ signaling but also for cell-specific events.

Therapeutic targeting K V 1.3 with specific peptides and small molecule inhibitors shows great potential for treating cancers and autoimmune diseases, such as multiple sclerosis, type I diabetes mellitus, psoriasis, contact dermatitis, rheumatoid arthritis, and myasthenia gravis.

2022年7月4日 · The Kv1.3 potassium channel is expressed abundantly on activated T cells and mediates the cellular immune response. This role has made the channel a target for therapeutic immunomodulation to block its activity and suppress T cell activation.

2021年2月6日 · Since the discovery of the Kv1.3 voltage-gated K+ channel in human T cells in 1984, ion channels are considered crucial elements of the signal transduction machinery in the immune system.