The interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2.

2017年12月6日 · Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic …

The IL-2 receptor (IL-2R) α subunit binds IL-2 with low affinity (K d ~ 10 −8 M). Interaction of IL-2 and CD25 alone does not lead to signal transduction due to its short intracellular chain but has …

Multiple studies demonstrated that the interleukin (IL)-2 – IL-2 receptor (IL-2R) pathway plays a pivotal role within these processes. The most striking functions of the IL-2 – IL-2R pathway are …

2018年8月8日 · IL-2 is produced primarily by CD4 + T cells, but high-affinity IL-2 receptors are expressed by both CD4 + and CD8 + T cells as well as other cell populations. Thus, antigen …

Interleukin-2 receptor (IL-2R) signaling regulates tolerance and immunity. Here, we review recent work concerning the structure, signaling, and function of the IL-2R, emphasizing the …

IL-2 is a pleiotropic cytokine, and dissecting the signaling pathways that allow IL-2 to control the differentiation and homeostasis of both pro- and anti-inflammatory T cells is fundamental to …

2020年9月1日 · Serum soluble interleukin-2 receptor is a useful biomarker for disease activity but not for differential diagnosis in IgG4-related disease and primary Sjögren's syndrome adults …

Interleukin-2 (IL-2), the first of a series of lymphocytotrophic hormones to be recognized and completely characterized, is pivotal for the generation and regulation of the immune response. …

2006年8月1日 · IL-2 is a secreted cytokine and binds pre-formed heterotrimeric receptors on the surface of activated cells. By contrast, IL-15 is mainly membrane bound, and it induces …