Interleukin 1 receptor-like 1, also known as IL1RL1 and ST2, is a protein that in humans is encoded by the IL1RL1 gene. [5][6][7] IL1RL1 is a member of the Toll-like receptor superfamily based on the function of its intracellular TIR domain, but its extracellular region is composed of immunoglobulin domains.

2024年12月25日 · IL1RL1 (Interleukin 1 Receptor Like 1) is a Protein Coding gene. Diseases associated with IL1RL1 include Chicken Egg Allergy and Conjunctivitis. Among its related pathways are IL-1 Family Signaling Pathways and Constitutive Signaling by Aberrant PI3K in …

Interleukin 1 receptor-like 1 (IL1RL1), also called T1, ST2, DER4 and FIT-1, is a member of the interleukin 1 super-family [1] but does not bind interleukin 1 (IL1) [2]. IL1RL1 was an orphan receptor until the description of its ligand, interleukin-33 (IL33) in 2005 [3].

IL-33 drives type 2 responses by inducing signalling through its receptor IL-1RL1 in several immune and structural cells, thereby leading to type 2 cytokine and chemokine production. IL-1RL1 gene transcript encodes different isoforms generated through alternative splicing.

An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-epsilon4 in female patients with Alzheimer's disease.

2025年2月8日 · IL1RL1 encodes a member of the interleukin 1 receptor family. IL1RL1 has been confused in the published literature with ST2 (GeneID: 6761) on chromosome 11 which is a region that represents a putative locus associated with various forms of cancer.

2024年12月19日 · In the current study, we investigated whether IL1RL1 gene variants are associated with asthma exacerbations (based on ER visits/hospitalizations and courses of oral corticosteroid [OCS] use), questionnaire‐based asthma control and FeNO levels in asthma patients using ICS.

2019年2月11日 · One gene upregulated by Cbfb-MYH11 encodes the cytokine receptor IL1RL1 (ST2). IL1RL1 and its ligand IL-33 are known regulators of mature myeloid cells, but their roles in AML are not known.

2025年2月19日 · TGF-beta upregulates the expression of the IL-33 receptor gene Il1rl1 (also known as ST2) in innate lymphoid cells and common helper-like innate lymphoid progenitors. these data indicate a central role of IL-33/ST2 signaling in shaping an immunosuppressive environment during intestinal tumorigenesis.

To determine how IL1RL1 + T reg cells suppress antitumor immune responses, we examined genes that are specifically up-regulated in IL1RL1 + T reg cells and have an immune suppression function. To this end, we analyzed our two rounds of scRNA-seq data.