Overview: IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.

2021年12月1日 · Interleukin-7 (IL-7), a molecule known for its growth-promoting effects on progenitors of B cells, remains one of the most extensively studied cytokines. It ...

2019年11月19日 · In their Review, Barata, Durum and Seddon describe IL-7’s key homeostatic functions and how its dysregulation can lead to autoinflammatory disease and cancer.

IL-7 signaling through the IL-7 receptor (IL-7R) plays a critical role in the survival of CD4 and CD8 double-negative (DN) thymocytes during early T-cell development. 1,4 DN thymocytes can be divided into four populations known as DN1 (CD44 + CD25 −), DN2 (CD44 + CD25 +), DN3 (CD44 − CD25 +) and DN4 (CD44 − CD25 −). 1,5 The development ...

Interleukin-7 (IL-7) is produced by stromal cells, keratinocytes, and epithelial cells in host tissues or tumors and exerts a wide range of immune effects mediated by the IL-7 receptor (IL-7R). IL-7 is primarily involved in regulating the ...

IL-7’s essential properties as a required factor for lymphocyte development and modulator of T cell homeostasis make it an attractive candidate for modulating immunodeficiency and augmenting immune based therapies, but also render it a plausible culprit in human disease.

2022年12月1日 · IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind Type I cytokine receptors. It is produced by stromal cells and is required for development and homeostatic survival of lymphoid cells.

2011年4月21日 · Interleukin-7 (IL-7) induces T cell proliferation and enhances antigen-specific immune responses: attributes that pinpoint its value as a potential therapeutic agent.

Cytokines IL-7 and IL-15 are essentially involved in T-cell homeostasis. IL-7 is required for developing mature T cells in the thymus, whereas in the periphery, it promotes the survival of naïve and memory T cells by upregulating the antiapoptotic molecule Bcl-2.

2002年6月1日 · IL-7 can be identified within the thymus of 13-day murine embryos coincident with the first wave of thymocyte expansion.19 The production of IL-7 has been identified in a subset of MHC class II+ epithelial cells21 that also express SCF, another important growth factor for early thymocytes.92 Interestingly, SCF synergizes with IL-7 in thymocyte ...