2024年12月25日 · IGF2BP3 (Insulin Like Growth Factor 2 MRNA Binding Protein 3) is a Protein Coding gene. Diseases associated with IGF2BP3 include Langerhans Cell Sarcoma and Keratoacanthoma. Among its related pathways are Processing of Capped Intron-Containing Pre-mRNA and Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind …

Insulin-like growth factor 2 mRNA-binding protein 3 is a protein that in humans is encoded by the IGF2BP3 gene. [ 5 ] [ 6 ] [ 7 ] The protein encoded by this gene is primarily found in the nucleolus , where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II ...

2024年8月28日 · Here, we identify that IGF2BP family proteins IGF2BP1-3 can preferentially bind internal mRNA m 7 G. Such interactions, especially IGF2BP3 with m 7 G, could promote the degradation of m 7 G...

2020年1月15日 · The IGF2BP3 gene (also known as IMP3, KOC, CT98, KOC1, and VICKZ3) is located on chromosome 7p15.3 in humans (Monk et al., 2002) and encodes a 69 kDa protein; this gene was first identified by Mueller-Pillasch et al. (1997) …

2025年2月9日 · IGF2BP3 is the first biomarker of prognostic significance in ovarian clear cell carcinoma that has been validated in an independent case series. Adenocarcinoma in situ of the uterine cervix demonstrate significant expression of IMP3.

2024年3月6日 · IGF2BP3 expression is significantly elevated in GC tissues and associated with poor prognosis of GC patients. Knockdown of IGF2BP3 significantly weakens the migration and clonogenic...

2020年1月15日 · Among the RBPs, insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) is of particular interest in tumorigenesis and tumor progression. This review highlights the molecular mechanisms underlying the oncogenic functions of IGF2BP3, summarizes the therapeutic potential related to its inhibition and notes the fundamental issues that remain ...

The insulin-like growth factor-2 mRNA-binding proteins 1, 2, and 3 (IGF2BP1, IGF2BP2, IGF2BP3) belong to a conserved family of RNA-binding, oncofetal proteins. Several studies have shown that these proteins act in various important aspects of cell function, such as cell polarization, migration, morp …

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BP1, IGF2BP2, and IGF2BP3) are a family of RNA-binding proteins that play an essential role in the development and disease by regulating mRNA stability and translation of critical regulators of cell division and metabolism.

2025年2月9日 · IMP3 is a widely used alternative name for insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3), which can be confused with the official symbol for IMP3, U3 small nucleolar ribonucleoprotein (IMP3).