Understanding the molecular and functional properties of IgG3 may facilitate the development of improved Ab-based immunotherapies and vaccines against infectious diseases.

IgG is divided into four subclasses: IgG1, IgG2, IgG3, and IgG4. People are said to have an IgG subclass deficiency when they lack or have very low levels of one or two IgG subclasses, but …

Of the five immunoglobulin isotypes, immunoglobulin G (IgG) is most abundant in human serum. The four subclasses, IgG1, IgG2, IgG3, and IgG4, which are highly conserved, differ in their …

The IgG3, though of relatively low affinity, allows IgG-mediated defences to join IgM-mediated defences in clearing foreign antigens. Subsequently, higher affinity IgG1 and IgG2 are …

Evidence suggests that the IgG3 hinge may allow targeting of antigens or epitopes less suited to ligation by other IgG types, with the potential to more effectively stimulate cellular activity via …

2019年2月8日 · IgG3 has been associated with enhanced control or protection against a range of intracellular bacteria, parasites, and viruses. IgG3 Abs are potent mediators of effector …

2024年1月23日 · IgG3. IgG3 comprises around 5 to 10% of total IgG and has a molecular weight of 170 kDa. They play a major role in the immune responses against protein or polypeptide …

IgG1 and IgG3 respond to protein antigens. They are T-dependent antigens; IgG2 and IgG4 respond to polysaccharide antigens, which are T-independent antigens. IgG functions by …

2025年3月20日 · IgG3 is the most potent activator of complement among the IgG subclasses, making it highly effective in immune complex formation and complement-dependent …

2022年6月24日 · IgG3 comprises around 5 to 10% of total IgG and plays a major role in the immune responses against protein or polypeptide antigens. Comprising usually less than 4% …