The inositol 1,4,5-trisphosphate (IP 3) receptor (IP 3 R) is a Ca 2+-release channel mainly located in the endoplasmic reticulum (ER).Three IP 3 R isoforms are responsible for the generation of intracellular Ca 2+ signals that may spread across the entire cell or occur locally in so-called microdomains. Because of their ubiquitous expression, these channels are involved in the …

The IP3R [IP3 (inositol 1,4,5-trisphosphate) receptor] is responsible for Ca2+ release from the ER (endoplasmic reticulum). We have been working extensively on the P400 protein, which is deficient in Purkinje-neuron-degenerating mutant mice.

2019年8月19日 · Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell...

In both nonexcitable and excitable cells, the inositol 1,4,5-trisphosphate receptor (IP3R) is the primary cytosolic target responsible for the initiation of intracellular calcium (Ca2+) signaling. ...

This brilliant investigation offered new and precious information for designing new compounds as potent IP3R agonists. Another potent IP3R ligand was synthesized conjugating an aromatic group at the 5’-position of AdA, and this addition was well tolerated in the receptor binding .

It is intriguing that the unique expression and co-expression of the three IP3R subtypes in different cell types might result in discrepancies in intracellular Ca 2+ homeostasis regulation. In light of this, while delving into the investigation of IP3R3, it might be judicious to …

2022年3月17日 · A pivotal component of the calcium (Ca2+) signaling toolbox in cells is the inositol 1,4,5-triphosphate (IP3) receptor (IP3R), which mediates Ca2+ release from the endoplasmic reticulum (ER ...

Inositol 1,4,5-trisphosphate receptors (IP3R) and their relatives, ryanodine receptors, are the channels that most often mediate Ca2+ release from intracellular stores. Their regulation by Ca2+ allows them also to propagate cytosolic Ca2+ signals ...

The inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) type 2 (IP3R2) is an intracellular Ca²⁺-release channel located on the endoplasmic reticulum (ER). IP3R2 is characterized by a high sensitivity to both IP3 and ATP and is biphasically regulated by Ca²⁺.

trisphosphate (IP3R) sont des canaux intracellulaires de libération du calcium impliqués dans diverses voies de signalisation. On pense que l'IP3R joue un rôle dans la mobilisation du calcium nécessaire à l'activation des lymphocytes T. L'IP3R est une structure tétramérique