Insulin-like growth factor 2 receptor (IGF2R), also called the cation-independent mannose-6-phosphate receptor (CI-MPR) is a protein that in humans is encoded by the IGF2R gene.

2024年12月25日 · IGF2R (Insulin Like Growth Factor 2 Receptor) is a Protein Coding gene. Diseases associated with IGF2R include Hepatocellular Carcinoma and Pompe Disease. …

IGF2R gene polymorphism and circulating IGF2R are associated with T2DM; Results show that insulin-like growth factor II (IGF-II) overexpression enhanced the levels of amyloid precursor …

The insulin-like growth factor 2 receptor (IGF2R) plays a major role in binding and regulating the circulating and tissue levels of the mitogenic peptide insulin-like growth factor 2 (IGF2). …

2025年2月8日 · Title: Dysfunction in IGF2R Pathway and Associated Perturbations in Autophagy and WNT Processes in Beckwith-Wiedemann Syndrome Cell Lines. CircTHBS1 promotes …

IGF2R is a multifunctional receptor that possesses binding sites for diverse ligands, including insulin-like growth factor II (IGF2; 147470), retinoic acid, TGF-beta (TGFB1; 190180), …

2007年11月29日 · IGF2R sequesters IGF‐II; imbalances occur in cancers and IGF2R is implicated in tumour suppression. We report crystal structures of IGF2R domains 11–12, …

2020年11月25日 · We demonstrate that IGF2 exhibits dual and opposing roles in controlling inflammatory phenotypes in macrophages by regulating glucose metabolism, relying on the …

2024年3月23日 · IGF2 exhibits a relatively weak binding to IR site-2 compared to insulin, making it less potent in promoting full IR activation. Cell-based experiments validated the functional …

Insulin-like growth factor 2 receptor (IGF2R), also known as cation-independent mannose 6-phosphate (M6P) receptor, is a transmembrane glycoprotein localized in the trans- Golgi …