HOXC10 is overexpressed in breast cancer and transcriptionally regulated by estrogen via involvement of histone methylases MLL3 and MLL4. [7] Methylation of the estrogen-repressed gene HOXC10 in breast cancer determines resistance to aromatase inhibitors. This epigenetic reprogramming of HOXC10 is observed in endocrine-resistant breast cancer. [8]

2024年12月25日 · HOXC10 (Homeobox C10) is a Protein Coding gene. Diseases associated with HOXC10 include Immunodeficiency 54. Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is HOXD10.

2021年5月25日 · HOXC10 also induces drug resistance in cancers by promoting the DNA repair pathway. In this review, we summarize HOXC10 gene structure and expression as well as the role of HOXC10 in different human cancer processes.

2021年5月24日 · In this review, we summarized the mechanism of HOXC10 in tumorigenesis and found that abnormal HOXC10 expression induced tumor occurrence by regulating cell proliferation, cycles, apoptosis, and angiogenesis and by avoiding immune destruction.

Homeodomain‑containing gene 10 (HOXC10) is a member of the homeobox transcription factors that plays an important role in the development of multicellular organisms. HOXC10 is overexpressed in a variety of human cancers, and recent studies have revealed that HOXC10 is upregulated in gastric cancer a …

同源盒 C10： 该基因属于同源盒基因家族。同源框基因编码一个高度保守的转录因子家族，在所有多细胞生物的形态发生中起着重要作用。哺乳动物拥有 4 个相似的同源盒基因簇 HOXA、HOXB、HOXC 和 HOXD，它们分别位于不同的染色体上，由 9～11 个串联排列的基因组成。该基因是位于 12 号染色体簇中的 ...

Homeobox gene C10 (HOXC10) plays a vital role in the occurrence and development of several cancers, but its effects and underlying mechanism in the prognosis of different subtypes of breast cancer remain unclear. First, we evaluated and compared the ...

2018年10月23日 · Our findings demonstrated that HOXC10 and its antisense transcript partner lncHOXC-AS3 had crucial function on the osteogenesis of MSCs derived from MM. We explored that overexpression of lncHOXC-AS3 could repress osteogenesis of MM-MSCs through targeting HOXC10 transcription.

Gastric cancer is one of the most common malignant tumors in the world. Recently reported, aberrations in HoxC10 expression was implicated in the proliferation, apoptosis, invasion and metastasis of cancer cells, which was related to the MAPK pathway, NF-κB pathway, and upregulating proinflammatory cytokines.

We found that HOXC10 expression increased in clinical samples, especially in poorly differentiated (PD) gastric cancer cells. Silencing HOXC10 suppressed proliferation, migration, and invasion in vitro, and inhibited tumor growth and induced apoptosis in vivo. Overexpression of HOXC10 showed the opposite effect on PD gastric cancer cells.